Decorin deficiency promotes epithelial-mesenchymal transition and colon cancer metastasis.
Animals
Azoxymethane
/ toxicity
Cadherins
/ genetics
Cancer-Associated Fibroblasts
/ drug effects
Celecoxib
/ toxicity
Colitis-Associated Neoplasms
/ chemically induced
Colonic Neoplasms
/ chemically induced
Decorin
/ genetics
Epithelial-Mesenchymal Transition
/ drug effects
Extracellular Matrix
/ drug effects
Humans
Mice
Neoplasm Metastasis
Proteoglycans
/ genetics
Tumor Microenvironment
/ drug effects
beta Catenin
/ genetics
AOM/DS
Celecoxib
Colorectal cancer
Decorin
EMT
Tumor microenvironment
Journal
Matrix biology : journal of the International Society for Matrix Biology
ISSN: 1569-1802
Titre abrégé: Matrix Biol
Pays: Netherlands
ID NLM: 9432592
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
09
07
2020
revised:
02
10
2020
accepted:
02
10
2020
pubmed:
17
10
2020
medline:
29
10
2021
entrez:
16
10
2020
Statut:
ppublish
Résumé
The tumor microenvironment encompasses a complex cellular network that includes cancer-associated fibroblasts, inflammatory cells, neo-vessels, and an extracellular matrix enriched in angiogenic growth factors. Decorin is one of the main components of the tumor stroma, but it is not expressed by cancer cells. Lack of this proteoglycan correlates with down-regulation of E-cadherin and induction of β-catenin signaling. In this study, we investigated the role of a decorin-deficient tumor microenvironment in colon carcinoma progression and metastasis. We utilized an established model of colitis-associated cancer by administering Azoxymethane/Dextran sodium sulfate to adult wild-type and Dcn
Identifiants
pubmed: 33065248
pii: S0945-053X(20)30091-3
doi: 10.1016/j.matbio.2020.10.001
pmc: PMC7870527
mid: NIHMS1637207
pii:
doi:
Substances chimiques
CTNNB1 protein, mouse
0
Cadherins
0
DCN protein, human
0
Dcn protein, mouse
0
Decorin
0
Proteoglycans
0
beta Catenin
0
Celecoxib
JCX84Q7J1L
Azoxymethane
MO0N1J0SEN
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-14Subventions
Organisme : NCI NIH HHS
ID : R01 CA039481
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no conflict of interest
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