Dietary Fatty Acids in Postprandial Triglyceride-Rich Lipoproteins Modulate Human Monocyte-Derived Dendritic Cell Maturation and Activation.
Adult
B7-1 Antigen
/ genetics
Cell Differentiation
Cells, Cultured
Dendritic Cells
/ immunology
Dietary Fats
/ administration & dosage
Fatty Acids
/ administration & dosage
Female
Gene Expression
Granulocyte-Macrophage Colony-Stimulating Factor
/ blood
Homeostasis
/ drug effects
Humans
Interleukin-3 Receptor alpha Subunit
/ genetics
Lipoproteins
/ metabolism
Male
Meals
Monocytes
Olive Oil
Postprandial Period
/ immunology
Triglycerides
/ metabolism
chylomicron
dendritic cells
fatty acids
myeloid lineage
olive oil
postprandial state
triglyceride-rich lipoprotein
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
14 Oct 2020
14 Oct 2020
Historique:
received:
13
08
2020
revised:
10
10
2020
accepted:
12
10
2020
entrez:
17
10
2020
pubmed:
18
10
2020
medline:
20
4
2021
Statut:
epublish
Résumé
Dietary fatty acids have been demonstrated to modulate systemic inflammation and induce the postprandial inflammatory response of circulating immune cells. We hypothesized that postprandial triglyceride-rich lipoproteins (TRLs) may have acute effects on immunometabolic homeostasis by modulating dendritic cells (DCs), sentinels of the immunity that link innate and adaptive immune systems. In healthy volunteers, saturated fatty acid (SFA)-enriched meal raised serum levels of granulocyte/macrophage colony-stimulating factor GM-CSF (SFAs > monounsaturated fatty acids (MUFAs) = polyunsaturated fatty acids (PUFAs)) in the postprandial period. Autologous TRL-SFAs upregulated the gene expression of DC maturation (
Identifiants
pubmed: 33066622
pii: nu12103139
doi: 10.3390/nu12103139
pmc: PMC7656296
pii:
doi:
Substances chimiques
B7-1 Antigen
0
CD80 protein, human
0
Dietary Fats
0
Fatty Acids
0
IL3RA protein, human
0
Interleukin-3 Receptor alpha Subunit
0
Lipoproteins
0
Olive Oil
0
Triglycerides
0
Granulocyte-Macrophage Colony-Stimulating Factor
83869-56-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía
ID : US-1263458
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