Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits.
Animals
BCG Vaccine
/ administration & dosage
CD8-Positive T-Lymphocytes
/ drug effects
Diabetes Mellitus, Type 2
/ complications
Female
Guinea Pigs
Humans
Hypoglycemic Agents
/ administration & dosage
Male
Metformin
/ administration & dosage
Mice
Mycobacterium tuberculosis
/ drug effects
Tuberculosis
/ etiology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
16 10 2020
16 10 2020
Historique:
received:
06
01
2020
accepted:
28
09
2020
entrez:
17
10
2020
pubmed:
18
10
2020
medline:
18
11
2020
Statut:
epublish
Résumé
Patients with type 2 diabetes (T2D) have a lower risk of Mycobacterium tuberculosis infection, progression from infection to tuberculosis (TB) disease, TB morality and TB recurrence, when being treated with metformin. However, a detailed mechanistic understanding of these protective effects is lacking. Here, we use mass cytometry to show that metformin treatment expands a population of memory-like antigen-inexperienced CD8
Identifiants
pubmed: 33067434
doi: 10.1038/s41467-020-19095-z
pii: 10.1038/s41467-020-19095-z
pmc: PMC7567856
doi:
Substances chimiques
BCG Vaccine
0
Hypoglycemic Agents
0
Metformin
9100L32L2N
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5225Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL081149
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL152078
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI111224
Pays : United States
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