Molecular detection and characterization of Carnivore chaphamaparvovirus 1 in dogs.
Animals
Capsid Proteins
/ genetics
Case-Control Studies
Diarrhea
/ veterinary
Dog Diseases
/ virology
Dogs
/ virology
Feces
/ virology
Genome, Viral
Host Specificity
Italy
Parvoviridae Infections
/ diagnosis
Parvovirus, Canine
/ classification
Pets
/ virology
Phylogeny
Viral Nonstructural Proteins
/ genetics
Canine chaphamaparvovirus 1
Dogs
Enteric samples
Parvoviridae
Journal
Veterinary microbiology
ISSN: 1873-2542
Titre abrégé: Vet Microbiol
Pays: Netherlands
ID NLM: 7705469
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
06
08
2020
accepted:
28
09
2020
pubmed:
18
10
2020
medline:
15
12
2020
entrez:
17
10
2020
Statut:
ppublish
Résumé
Canine chaphamaparvovirus (CaChPV) is a newly recognised parvovirus discovered by metagenomic analysis during an outbreak of diarrhoea in dogs in Colorado, USA, in 2017 and more recently detected in diarrhoeic dogs in China. Whether the virus plays a role as canine pathogen and whether it is distributed elsewhere, in other geographical areas, is not known. We performed a case-control study to investigate the possible association of CaChPV with enteritis in dogs. CaChPV DNA was detected both in the stools of diarrhoeic dogs (1.9 %, 3/155) and of healthy animals (1.6 %, 2/120). All the CaChPV-infected dogs with diarrhea were mixed infected with other enteric viruses such as canine parvovirus (formerly CPV-2), canine bufavirus (CBuV) and canine coronavirus (CCoV), whilst none of the asymptomatic CaChPV positive animals resulted co-infected. The nearly full-length genome and the partial capsid protein (VP) gene of three canine strains, Te/36OVUD/19/ITA, Te/37OVUD/19/ITA and Te/70OVUD/19/ITA, were reconstructed. Upon phylogenetic analyses based on the NS1 and VP aa sequences, the Italian CaChPV strains tightly clustered with the American reference viruses. Distinctive residues could be mapped to the deduced variable regions of the VP of canine and feline chaphamaparvoviruses, considered as important markers of host range and pathogenicity for parvoviruses.
Identifiants
pubmed: 33069035
pii: S0378-1135(20)31016-6
doi: 10.1016/j.vetmic.2020.108878
pmc: PMC7528909
pii:
doi:
Substances chimiques
Capsid Proteins
0
NS1 protein, parvovirus
0
Viral Nonstructural Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
108878Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
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