Neonatal Serotonin Depletion Induces Hyperactivity and Anxiolytic-like Sex-Dependent Effects in Adult Rats.
Aging
/ pathology
Amygdala
/ metabolism
Animals
Animals, Newborn
Anti-Anxiety Agents
/ metabolism
Body Weight
Brain
/ metabolism
Dorsal Raphe Nucleus
/ metabolism
Elevated Plus Maze Test
Feeding Behavior
Female
Gene Expression Regulation
Male
Open Field Test
Paraventricular Hypothalamic Nucleus
/ metabolism
Prefrontal Cortex
/ metabolism
RNA, Messenger
/ genetics
Rats
Serotonin
/ deficiency
Sex Characteristics
Social Interaction
Swimming
Anxiety
Locomotion
Ontogenetic period
Perinatal programming
Serotonin
pCPA
Journal
Molecular neurobiology
ISSN: 1559-1182
Titre abrégé: Mol Neurobiol
Pays: United States
ID NLM: 8900963
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
29
06
2020
accepted:
14
10
2020
pubmed:
22
10
2020
medline:
14
10
2021
entrez:
21
10
2020
Statut:
ppublish
Résumé
The serotoninergic system plays an important role in the ontogeny of the mammalian central nervous system, and changes in serotonin production during development may lead to permanent changes in brain cytoarchitecture and function. The present study investigated the programming effects of neonatal serotonin depletion on behavior and molecular components of the serotoninergic system in adult male and female rats. Subcutaneous para-chlorophenylalanine (pCPA) administration (100 mg kg
Identifiants
pubmed: 33083963
doi: 10.1007/s12035-020-02181-0
pii: 10.1007/s12035-020-02181-0
doi:
Substances chimiques
Anti-Anxiety Agents
0
RNA, Messenger
0
Serotonin
333DO1RDJY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1036-1051Subventions
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2016/17968-6
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 308893/2018-2
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 010239/2016-2
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 423854/2018-6
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 88887.374200/2019-00
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