Metal Ion Promiscuity and Structure of 2,3-Dihydroxybenzoic Acid Decarboxylase of Aspergillus oryzae.
biocatalysis
computational chemistry
enzyme structure
metal-identity
ortho-benzoic acid decarboxylase
Journal
Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360
Informations de publication
Date de publication:
15 02 2021
15 02 2021
Historique:
received:
26
08
2020
revised:
06
10
2020
pubmed:
23
10
2020
medline:
28
9
2021
entrez:
22
10
2020
Statut:
ppublish
Résumé
Broad substrate tolerance and excellent regioselectivity, as well as independence from sensitive cofactors have established benzoic acid decarboxylases from microbial sources as efficient biocatalysts. Robustness under process conditions makes them particularly attractive for preparative-scale applications. The divalent metal-dependent enzymes are capable of catalyzing the reversible non-oxidative (de)carboxylation of a variety of electron-rich (hetero)aromatic substrates analogously to the chemical Kolbe-Schmitt reaction. Elemental mass spectrometry supported by crystal structure elucidation and quantum chemical calculations verified the presence of a catalytically relevant Mg
Identifiants
pubmed: 33090643
doi: 10.1002/cbic.202000600
pmc: PMC7894528
doi:
Substances chimiques
Hydroxybenzoates
0
2,3-dihydroxybenzoic acid
70D5FBB392
Carboxy-Lyases
EC 4.1.1.-
Magnesium
I38ZP9992A
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
652-656Subventions
Organisme : Helmholtz Association HGF
Organisme : University of Graz
ID : F04604
Organisme : Austrian BMWFW, BMVIT, SFG, Standortagentur Tirol, Government of Lower Austria and ZIT
ID : I 1637-N19
Organisme : Austrian BMWFW, BMVIT, SFG, Standortagentur Tirol, Government of Lower Austria and ZIT
ID : P 26863-N19
Informations de copyright
© 2020 The Authors. ChemBioChem published by Wiley-VCH GmbH.
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