Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020.
Adaptive Immunity
Aging
Analgesics
/ pharmacology
Angiogenesis Inducing Agents
/ pharmacology
Anti-Inflammatory Agents, Non-Steroidal
/ pharmacology
Cellular Senescence
Humans
Immunity, Innate
In Vitro Techniques
Osteoarthritis
/ therapy
Platelet Transfusion
/ methods
Platelet-Rich Plasma
/ cytology
Rehabilitation
Serotonin
/ metabolism
Terminology as Topic
analgesic effects
angiogenesis
immunomodulation
inflammation
lymphocytes
monocytes
neutrophils
platelet dosing
platelet-rich plasma
regenerative medicine
rehabilitation
serotonin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Oct 2020
21 Oct 2020
Historique:
received:
02
10
2020
revised:
17
10
2020
accepted:
19
10
2020
entrez:
24
10
2020
pubmed:
25
10
2020
medline:
17
4
2021
Statut:
epublish
Résumé
Emerging autologous cellular therapies that utilize platelet-rich plasma (PRP) applications have the potential to play adjunctive roles in a variety of regenerative medicine treatment plans. There is a global unmet need for tissue repair strategies to treat musculoskeletal (MSK) and spinal disorders, osteoarthritis (OA), and patients with chronic complex and recalcitrant wounds. PRP therapy is based on the fact that platelet growth factors (PGFs) support the three phases of wound healing and repair cascade (inflammation, proliferation, remodeling). Many different PRP formulations have been evaluated, originating from human, in vitro, and animal studies. However, recommendations from in vitro and animal research often lead to different clinical outcomes because it is difficult to translate non-clinical study outcomes and methodology recommendations to human clinical treatment protocols. In recent years, progress has been made in understanding PRP technology and the concepts for bioformulation, and new research directives and new indications have been suggested. In this review, we will discuss recent developments regarding PRP preparation and composition regarding platelet dosing, leukocyte activities concerning innate and adaptive immunomodulation, serotonin (5-HT) effects, and pain killing. Furthermore, we discuss PRP mechanisms related to inflammation and angiogenesis in tissue repair and regenerative processes. Lastly, we will review the effect of certain drugs on PRP activity, and the combination of PRP and rehabilitation protocols.
Identifiants
pubmed: 33096812
pii: ijms21207794
doi: 10.3390/ijms21207794
pmc: PMC7589810
pii:
doi:
Substances chimiques
Analgesics
0
Angiogenesis Inducing Agents
0
Anti-Inflammatory Agents, Non-Steroidal
0
Serotonin
333DO1RDJY
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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