Increased Regulatory T Cells Precede the Development of Bronchopulmonary Dysplasia in Preterm Infants.

Adult Bronchopulmonary Dysplasia / immunology Cohort Studies Female Flow Cytometry Forkhead Transcription Factors / metabolism Gestational Age HLA-DR Antigens / metabolism Humans Immunophenotyping Infant, Newborn Infant, Premature / immunology Interleukin-2 Receptor alpha Subunit / metabolism Lymphocyte Activation Pregnancy T-Lymphocytes, Regulatory / immunology
BPD Foxp3 Tregs bronchopulmonary dysplasia neonate preterm infant regulatory T cells

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2020
Historique:
received: 04 06 2020
accepted: 31 08 2020
entrez: 26 10 2020
pubmed: 27 10 2020
medline: 4 6 2021
Statut: epublish

Résumé

Regulatory T cells (Tregs) are important for the ontogenetic control of immune activation and tissue damage in preterm infants. However, the role of Tregs for the development of bronchopulmonary dysplasia (BPD) is yet unclear. The aim of our study was to characterize CD4+ CD25+ forkhead box protein 3 (FoxP3)+ Tregs in peripheral blood of well-phenotyped preterm infants (

Identifiants

DOI: 10.3389/fimmu.2020.565257 PMID: 33101284 PMC: PMC7554370
pubmed: 33101284
doi: 10.3389/fimmu.2020.565257
pmc: PMC7554370
doi:

Substances chimiques

FOXP3 protein, human 0
Forkhead Transcription Factors 0
HLA-DR Antigens 0
Interleukin-2 Receptor alpha Subunit 0

Types de publication

Journal Article Observational Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

565257

Informations de copyright

Copyright © 2020 Pagel, Twisselmann, Rausch, Waschina, Hartz, Steinbeis, Olbertz, Nagel, Steinmetz, Faust, Demmert, Göpel, Herting, Rupp and Härtel.

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Auteurs

Julia Pagel (J)

Department of Pediatrics, University of Lübeck, Lübeck, Germany.
Department of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.
German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Lübeck, Germany.
Department of Pediatrics, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

Nele Twisselmann (N)

Department of Pediatrics, University of Lübeck, Lübeck, Germany.

Tanja K Rausch (TK)

Department of Pediatrics, University of Lübeck, Lübeck, Germany.
Department of Medical Biometry and Statistics, University of Lübeck, Lübeck, Germany.

Silvio Waschina (S)

Research Group Medical Systems Biology, Christian-Albrechts-University Kiel, Kiel, Germany.

Annika Hartz (A)

Department of Pediatrics, University of Lübeck, Lübeck, Germany.

Magdalena Steinbeis (M)

Department of Pediatrics, University of Lübeck, Lübeck, Germany.

Jonathan Olbertz (J)

Department of Pediatrics, University of Lübeck, Lübeck, Germany.

Kathrin Nagel (K)

Department of Pediatrics, University of Lübeck, Lübeck, Germany.

Alena Steinmetz (A)

Department of Pediatrics, University of Lübeck, Lübeck, Germany.

Kirstin Faust (K)

Department of Pediatrics, University of Lübeck, Lübeck, Germany.

Martin Demmert (M)

Department of Pediatrics, University of Lübeck, Lübeck, Germany.

Wolfgang Göpel (W)

Department of Pediatrics, University of Lübeck, Lübeck, Germany.

Egbert Herting (E)

Department of Pediatrics, University of Lübeck, Lübeck, Germany.

Jan Rupp (J)

Department of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.
German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Lübeck, Germany.

Christoph Härtel (C)

Department of Pediatrics, University of Lübeck, Lübeck, Germany.
German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Lübeck, Germany.
University Children's Hospital, University of Würzburg, Würzburg, Germany.
PRIMAL (Priming Immunity at the Beginning of Life) Consortium, Lübeck, Germany.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Increased Regulatory T Cells Precede the...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies néonatales › Maladies du prématuré › Dysplasie bronchopulmonaire › Increased Regulatory T Cells Precede the...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Increased Regulatory T Cells Precede the...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytophotométrie › Cytométrie en flux › Increased Regulatory T Cells Precede the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif hélice ailée › Facteurs de transcription Forkhead › Increased Regulatory T Cells Precede the...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Âge gestationnel › Increased Regulatory T Cells Precede the...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › Antigènes HLA-D › Antigènes HLA-DR › Increased Regulatory T Cells Precede the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Increased Regulatory T Cells Precede the...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Immunophénotypage › Increased Regulatory T Cells Precede the...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Increased Regulatory T Cells Precede the...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Prématuré › Increased Regulatory T Cells Precede the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux interleukines › Récepteurs à l'interleukine-2 › Sous-unité alpha du récepteur à l'interleukine-2 › Increased Regulatory T Cells Precede the...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Increased Regulatory T Cells Precede the...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Increased Regulatory T Cells Precede the...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Increased Regulatory T Cells Precede the...