Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson's Dementia in Humans.
Acyltransferases
/ deficiency
Animals
Brain-Derived Neurotrophic Factor
/ genetics
Cognition
/ physiology
Disease Models, Animal
Female
Gene Expression Regulation
Ghrelin
/ analogs & derivatives
Hippocampus
/ metabolism
Humans
Male
Membrane Proteins
/ deficiency
Mice
Mice, Inbred C57BL
Mice, Knockout
Neurogenesis
/ genetics
Neuronal Plasticity
/ genetics
Neurons
/ metabolism
Parkinson Disease
/ genetics
Primary Cell Culture
Rats
Signal Transduction
Spatial Memory
/ physiology
Supranuclear Palsy, Progressive
/ genetics
AG:UAG
BDNF
GOAT
Parkinson disease dementia
acyl-ghrelin
adult hippocampal neurogenesis
biomarker
ghrelin
memory
unacylated-ghrelin
Journal
Cell reports. Medicine
ISSN: 2666-3791
Titre abrégé: Cell Rep Med
Pays: United States
ID NLM: 101766894
Informations de publication
Date de publication:
20 10 2020
20 10 2020
Historique:
received:
05
11
2019
revised:
20
05
2020
accepted:
16
09
2020
entrez:
26
10
2020
pubmed:
27
10
2020
medline:
27
10
2020
Statut:
epublish
Résumé
Blood-borne factors regulate adult hippocampal neurogenesis and cognition in mammals. We report that elevating circulating unacylated-ghrelin (UAG), using both pharmacological and genetic methods, reduced hippocampal neurogenesis and plasticity in mice. Spatial memory impairments observed in ghrelin-O-acyl transferase-null (GOAT
Identifiants
pubmed: 33103129
doi: 10.1016/j.xcrm.2020.100120
pii: S2666-3791(20)30162-2
pmc: PMC7575905
doi:
Substances chimiques
Bdnf protein, mouse
0
Brain-Derived Neurotrophic Factor
0
Ghrelin
0
Membrane Proteins
0
acyl-ghrelin
0
Acyltransferases
EC 2.3.-
MBOAT4 protein, human
EC 2.3.-
Mboat4 protein, mouse
EC 2.3.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
100120Subventions
Organisme : Medical Research Council
ID : G0902250
Pays : United Kingdom
Informations de copyright
© 2020 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
Mol Psychiatry. 2015 Apr;20(4):500-8
pubmed: 24751964
Sci Rep. 2017 Mar 31;7:45541
pubmed: 28361877
J Neurochem. 2016 May;137(3):460-71
pubmed: 26872221
PLoS One. 2010 Jul 26;5(7):e11749
pubmed: 20668691
Science. 2009 Feb 20;323(5917):1074-7
pubmed: 19119186
Nature. 2017 Apr 27;544(7651):488-492
pubmed: 28424512
J Neurol. 2011 Jun;258(6):982-90
pubmed: 21181542
Nat Commun. 2016 Nov 22;7:13363
pubmed: 27874859
Nat Neurosci. 2004 Jul;7(7):726-35
pubmed: 15195095
Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6320-5
pubmed: 18443287
Hippocampus. 2013 Dec;23(12):1246-58
pubmed: 23804525
Psychoneuroendocrinology. 2016 Jan;63:198-207
pubmed: 26460782
Mov Disord. 2007 Dec;22(16):2314-24
pubmed: 18098298
PLoS One. 2014 May 22;9(5):e98180
pubmed: 24852945
J Neurochem. 2018 Jan;144(1):58-67
pubmed: 29063591
Nat Neurosci. 1999 Mar;2(3):266-70
pubmed: 10195220
Nature. 1999 Dec 9;402(6762):656-60
pubmed: 10604470
Peptides. 2006 Sep;27(9):2321-5
pubmed: 16687192
Trends Endocrinol Metab. 2019 Nov;30(11):844-859
pubmed: 31445747
Regul Pept. 2010 Sep 24;164(2-3):65-70
pubmed: 20619300
Neuron. 2010 Jan 14;65(1):7-19
pubmed: 20152109
J Neuroendocrinol. 2017 Oct;29(10):
pubmed: 28771924
Mol Cell Biol. 2003 Nov;23(22):7973-81
pubmed: 14585959
J Neurosci. 2012 Nov 21;32(47):16906-16
pubmed: 23175842
Cell. 2018 Aug 9;174(4):999-1014.e22
pubmed: 30096314
Gut. 2005 Jan;54(1):18-24
pubmed: 15591499
J Neurosci. 2004 Dec 8;24(49):11205-13
pubmed: 15590937
Cell Rep. 2013 Nov 14;5(3):759-68
pubmed: 24209752
Exp Neurol. 2009 Oct;219(2):543-52
pubmed: 19619535
J Biol Chem. 2002 Nov 29;277(48):46116-22
pubmed: 12359714
Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7467-72
pubmed: 20231469
Mol Cell Neurosci. 1997;8(6):389-404
pubmed: 9143557
Nat Rev Neurosci. 2018 Aug;19(8):485-498
pubmed: 29970909
Behav Neurosci. 1996 Dec;110(6):1321-34
pubmed: 8986335
Nat Rev Neurosci. 2001 Dec;2(12):880-8
pubmed: 11733795
Nat Rev Neurol. 2018 Nov;14(11):639-652
pubmed: 30297701
Nat Med. 2015 Aug;21(8):932-7
pubmed: 26147761
Endocr J. 2013;60(6):781-9
pubmed: 23411585
Annu Rev Neurosci. 1991;14:421-51
pubmed: 1903243
Nature. 2004 Jun 17;429(6993):761-6
pubmed: 15190253
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E149-58
pubmed: 24367106
Psychopharmacology (Berl). 2015 May;232(10):1843-57
pubmed: 25466701
J Clin Endocrinol Metab. 2005 Feb;90(2):1055-60
pubmed: 15536157
Sci Rep. 2017 Dec 4;7(1):16878
pubmed: 29203879
Neuron. 2011 May 26;70(4):589-96
pubmed: 21609818
Neurobiol Dis. 2011 Mar;41(3):706-16
pubmed: 21168496
Nat Med. 2014 Jun;20(6):659-63
pubmed: 24793238
J Neurosci. 1992 Jul;12(7):2685-705
pubmed: 1613552
Mov Disord. 2017 Oct;32(10):1487-1491
pubmed: 28681931
Science. 2018 Sep 7;361(6406):
pubmed: 30190379
Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14731-6
pubmed: 11121072
Trends Neurosci. 2010 Mar;33(3):121-9
pubmed: 20138375
Nature. 2011 Aug 31;477(7362):90-4
pubmed: 21886162
Science. 2009 Jul 10;325(5937):210-3
pubmed: 19590004
Neurosci Lett. 2012 May 16;516(2):280-4
pubmed: 22516464
Nature. 2005 Feb 17;433(7027):760-4
pubmed: 15716955
Psychoneuroendocrinology. 2015 Jan;51:431-9
pubmed: 25462915
Sci Transl Med. 2019 Aug 14;11(505):
pubmed: 31413143
Nat Neurosci. 2006 Mar;9(3):381-8
pubmed: 16491079
Cell. 2008 Feb 8;132(3):387-96
pubmed: 18267071
Endocrinology. 2005 Jan;146(1):355-64
pubmed: 15471959
Nature. 2011 Apr 28;472(7344):466-70
pubmed: 21460835
J Neuroendocrinol. 2016 Feb;28(2):12349
pubmed: 26661382
Science. 2014 May 9;344(6184):630-4
pubmed: 24797482