Activation of carbonic anhydrases from human brain by amino alcohol oxime ethers: towards human carbonic anhydrase VII selective activators.

Amino Alcohols / chemical synthesis Brain / drug effects Carbonic Anhydrases / metabolism Dose-Response Relationship, Drug Ethers / chemical synthesis Humans Isoenzymes / metabolism Molecular Structure Oximes / chemical synthesis Structure-Activity Relationship
CNS-disease Metalloenzyme activation cognition selectivity

Journal

Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203

Informations de publication

Date de publication:
Dec 2021
Historique:
entrez: 26 10 2020
pubmed: 27 10 2020
medline: 18 5 2021
Statut: ppublish

Résumé

The synthesis and carbonic anhydrase (CA; EC 4.2.1.1) activating effects of a series of oxime ether-based amino alcohols towards four human (h) CA isoforms expressed in human brain, hCA I, II, IV and VII, are described. Most investigated amino alcohol derivatives induced a consistent activation of the tested CAs, with K

Identifiants

DOI: 10.1080/14756366.2020.1838501 PMID: 33103482 PMC: PMC7594847
pubmed: 33103482
doi: 10.1080/14756366.2020.1838501
pmc: PMC7594847
doi:

Substances chimiques

Amino Alcohols 0
Ethers 0
Isoenzymes 0
Oximes 0
Carbonic Anhydrases EC 4.2.1.1
carbonic anhydrase VI EC 4.2.1.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

48-57

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Auteurs

Alessio Nocentini (A)

Section of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child's Health (Neurofarba), University of Florence, Sesto Fiorentino, Italy.
ORCID: 0000-0003-3342-702X

Doretta Cuffaro (D)

Department of Pharmacy, University of Pisa, Pisa, Italy.
ORCID: 0000-0002-8842-542X

Lidia Ciccone (L)

Department of Pharmacy, University of Pisa, Pisa, Italy.
ORCID: 0000-0002-2762-1929

Elisabetta Orlandini (E)

Department of Pharmacy, University of Pisa, Pisa, Italy.

Susanna Nencetti (S)

Department of Pharmacy, University of Pisa, Pisa, Italy.

Elisa Nuti (E)

Department of Pharmacy, University of Pisa, Pisa, Italy.
ORCID: 0000-0003-2669-5376

Armando Rossello (A)

Department of Pharmacy, University of Pisa, Pisa, Italy.
ORCID: 0000-0002-6795-8091

Claudiu T Supuran (CT)

Section of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child's Health (Neurofarba), University of Florence, Sesto Fiorentino, Italy.
ORCID: 0000-0003-4262-0323

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amines › Aminoalcools › Activation of carbonic anhydrases from human...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Activation of carbonic anhydrases from human...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › Carbon-oxygen lyases › Hydro-lyases › Carbonic anhydrases › Activation of carbonic anhydrases from human...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Activation of carbonic anhydrases from human...
questionsmedicales.fr › Composés chimiques organiques › Éthers › Activation of carbonic anhydrases from human...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Activation of carbonic anhydrases from human...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Isoformes de protéines › Isoenzymes › Activation of carbonic anhydrases from human...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Activation of carbonic anhydrases from human...
questionsmedicales.fr › Composés chimiques organiques › Amines › Hydroxylamines › Oximes › Activation of carbonic anhydrases from human...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Activation of carbonic anhydrases from human...