Flare Size but Not Intensity Reflects Histamine-Induced Itch.
Axon reflex flare
Capsaicin
Cowhage
Histamine
Itch
Pruritus
Journal
Skin pharmacology and physiology
ISSN: 1660-5535
Titre abrégé: Skin Pharmacol Physiol
Pays: Switzerland
ID NLM: 101188418
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
01
2020
accepted:
12
05
2020
pubmed:
27
10
2020
medline:
14
8
2021
entrez:
26
10
2020
Statut:
ppublish
Résumé
Flare reactions arise due to the release of vasodilators from sensory nerves caused by antidromic transmission of action potentials after the induction of itch. We investigated the link between flare and itch using 3 models of itch. Skin provocations with histamine, capsaicin, and cowhage were performed in 31 subjects. Itch was quantified using the visual analog scale. Flare was assessed using laser speckle contrast imaging (LSCI) and digital photography. The duration, intensity, and area under the curve of histamine-induced itch correlated with the area of increased blood flow measured with LSCI (r = 0.545, p = 0.002; r = 0.575, p = 0.001; and r = 0.649, p < 0.001, respectively). Itch and skin blood flow in response to capsaicin or cowhage did not correlate. In histamine-induced skin inflammation, itch and increased blood flow are linked. Thus, the area of histamine-induced flare may be used as a surrogate marker for histamine-induced itch.
Identifiants
pubmed: 33105140
pii: 000508795
doi: 10.1159/000508795
pmc: PMC7677997
doi:
Substances chimiques
Histamine
820484N8I3
Capsaicin
S07O44R1ZM
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
244-252Informations de copyright
© 2020 The Author(s) Published by S. Karger AG, Basel.
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