Interhelical interactions within the STIM1 CC1 domain modulate CRAC channel activation.
Blood Platelet Disorders
/ genetics
Calcium Release Activated Calcium Channels
/ metabolism
Cloning, Molecular
Dyslexia
/ genetics
Erythrocytes, Abnormal
HEK293 Cells
Humans
Ichthyosis
/ genetics
Magnetic Resonance Spectroscopy
Migraine Disorders
/ genetics
Miosis
/ genetics
Models, Molecular
Muscle Fatigue
/ genetics
Mutation
/ genetics
Neoplasm Proteins
/ genetics
Nucleic Acid Conformation
ORAI1 Protein
/ genetics
Patch-Clamp Techniques
Spleen
/ abnormalities
Stromal Interaction Molecule 1
/ genetics
Journal
Nature chemical biology
ISSN: 1552-4469
Titre abrégé: Nat Chem Biol
Pays: United States
ID NLM: 101231976
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
16
04
2020
accepted:
11
09
2020
revised:
04
09
2020
pubmed:
28
10
2020
medline:
9
3
2021
entrez:
27
10
2020
Statut:
ppublish
Résumé
The calcium release activated calcium channel is activated by the endoplasmic reticulum-resident calcium sensor protein STIM1. On activation, STIM1 C terminus changes from an inactive, tight to an active, extended conformation. A coiled-coil clamp involving the CC1 and CC3 domains is essential in controlling STIM1 activation, with CC1 as the key entity. The nuclear magnetic resonance-derived solution structure of the CC1 domain represents a three-helix bundle stabilized by interhelical contacts, which are absent in the Stormorken disease-related STIM1 R304W mutant. Two interhelical sites between the CC1α
Identifiants
pubmed: 33106661
doi: 10.1038/s41589-020-00672-8
pii: 10.1038/s41589-020-00672-8
pmc: PMC7610458
mid: EMS118356
doi:
Substances chimiques
Calcium Release Activated Calcium Channels
0
Neoplasm Proteins
0
ORAI1 Protein
0
ORAI1 protein, human
0
STIM1 protein, human
0
Stromal Interaction Molecule 1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
196-204Subventions
Organisme : Austrian Science Fund FWF
ID : W 1250
Pays : Austria
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