Functional Analysis of
1-Alkyl-2-acetylglycerophosphocholine Esterase
/ genetics
Animals
CHO Cells
Cell Adhesion Molecules, Neuronal
/ genetics
Cricetulus
Extracellular Matrix Proteins
/ genetics
HEK293 Cells
Humans
Mutation
Nerve Tissue Proteins
/ genetics
Reelin Protein
Serine Endopeptidases
/ genetics
Spondylitis, Ankylosing
/ genetics
THP-1 Cells
Ankylosing spondylitis
Inflammation
PLA2G7 protein
Platelet-activating factor acetylhydrolase
Reelin
Journal
Archives of Iranian medicine
ISSN: 1735-3947
Titre abrégé: Arch Iran Med
Pays: Iran
ID NLM: 100889644
Informations de publication
Date de publication:
01 10 2020
01 10 2020
Historique:
received:
15
04
2020
accepted:
04
07
2020
entrez:
27
10
2020
pubmed:
28
10
2020
medline:
17
8
2021
Statut:
epublish
Résumé
Ankylosing spondylitis (AS; OMIM:106300) is a common complex inflammatory disease; in a previous study, we introduced a novel mutation in the The impact of the S2486G on reelin protein secretion was investigated in CHO-K1 and HEK-293T cells by constructing wild-type and mutant plasmids. Besides, the possible effect of the mutation on expression and concentration of Our results showed that S2486G not only causes a significant reduction in reelin secretion in both HEK-293T and CHO-K1 cells, but also it leads to a significant reduction in The S2486G mutation in
Sections du résumé
BACKGROUND
Ankylosing spondylitis (AS; OMIM:106300) is a common complex inflammatory disease; in a previous study, we introduced a novel mutation in the
METHODS
The impact of the S2486G on reelin protein secretion was investigated in CHO-K1 and HEK-293T cells by constructing wild-type and mutant plasmids. Besides, the possible effect of the mutation on expression and concentration of
RESULTS
Our results showed that S2486G not only causes a significant reduction in reelin secretion in both HEK-293T and CHO-K1 cells, but also it leads to a significant reduction in
CONCLUSION
The S2486G mutation in
Identifiants
pubmed: 33107310
doi: 10.34172/aim.2020.87
doi:
Substances chimiques
Cell Adhesion Molecules, Neuronal
0
Extracellular Matrix Proteins
0
Nerve Tissue Proteins
0
Reelin Protein
0
1-Alkyl-2-acetylglycerophosphocholine Esterase
EC 3.1.1.47
PLA2G7 protein, human
EC 3.1.1.47
RELN protein, human
EC 3.4.21.-
Serine Endopeptidases
EC 3.4.21.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
688-696Informations de copyright
© 2020 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.