Coniferyl Alcohol Radical Detection by the Dirigent Protein AtDIR6 Monitored by EPR.
EPR
UV light
dirigent proteins
radicals
stereoselectivity
Journal
Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360
Informations de publication
Date de publication:
16 03 2021
16 03 2021
Historique:
revised:
13
10
2020
received:
15
09
2020
pubmed:
29
10
2020
medline:
20
11
2021
entrez:
28
10
2020
Statut:
ppublish
Résumé
Plant dirigent proteins (DIRs) control the stereoselectivity of the monolignol coniferyl alcohol radical coupling. The main mechanistic hypothesis on this chemo- and stereoselective reaction invokes a binding of coniferyl alcohol radical substrates in the dirigent protein active site so that only one enantiomeric form can be produced. We have studied the influence of the Arabidopsis thaliana AtDIR6 protein on the transient coniferyl alcohol radical by EPR. Herein, we show that AtDIR6 stabilizes coniferyl alcohol radicals prior to directing their coupling towards the formation of (-)-pinoresinol.
Identifiants
pubmed: 33112043
doi: 10.1002/cbic.202000650
doi:
Substances chimiques
Arabidopsis Proteins
0
DIR6 protein, Arabidopsis
0
Free Radicals
0
Phenols
0
coniferyl alcohol
E7SM92591P
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
992-995Subventions
Organisme : CNRS
Organisme : Aix Marseille Université
Organisme : Graduate School of Chemistry of AMU
Organisme : Agence Nationale de la Recherche
ID : ANR-09-BLANC-0176
Informations de copyright
© 2020 Wiley-VCH GmbH.
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