Inhibition of the alternative lengthening of telomeres pathway by subtelomeric sequences in Saccharomyces cerevisiae.

Cellular Senescence Rad51 Recombinase / metabolism Rad52 DNA Repair and Recombination Protein / metabolism Recombination, Genetic Regulatory Sequences, Nucleic Acid Saccharomyces cerevisiae / genetics Saccharomyces cerevisiae Proteins / metabolism Telomerase Telomere / metabolism Telomere Homeostasis
Budding yeast Rad52 Replicative senescence Subtelomeric Y’ elements Telomerase-independent telomere maintenance Telomere recombination

Journal

DNA repair
ISSN: 1568-7856
Titre abrégé: DNA Repair (Amst)
Pays: Netherlands
ID NLM: 101139138

Informations de publication

Date de publication:
12 2020
Historique:
received: 05 06 2020
revised: 24 09 2020
accepted: 04 10 2020
pubmed: 31 10 2020
medline: 1 4 2021
entrez: 30 10 2020
Statut: ppublish

Résumé

In the budding yeast Saccharomyces cerevisiae, telomerase is constitutively active and is essential for chromosome end protection and illimited proliferation of cell populations. However, upon inactivation of telomerase, alternative mechanims of telomere maintenance allow proliferation of only extremely rare survivors. S. cerevisiae type I and type II survivors differ by the nature of the donor sequences used for repair by homologous recombination of the uncapped terminal TG

Identifiants

DOI: 10.1016/j.dnarep.2020.102996 PMID: 33126043
pubmed: 33126043
pii: S1568-7864(20)30256-1
doi: 10.1016/j.dnarep.2020.102996
pii:
doi:

Substances chimiques

RAD52 protein, S cerevisiae 0
Rad52 DNA Repair and Recombination Protein 0
Saccharomyces cerevisiae Proteins 0
RAD51 protein, S cerevisiae EC 2.7.7.-
Rad51 Recombinase EC 2.7.7.-
Telomerase EC 2.7.7.49

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102996

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Nathalie Grandin (N)

GReD Institute, CNRS UMR6293, INSERM U1103, Faculty of Medicine, University Clermont-Auvergne, 28 place Henri Dunant, BP 38, 63001 Clermont-Ferrand Cedex, France.

Maria Eugenia Gallego (ME)

GReD Institute, CNRS UMR6293, INSERM U1103, Faculty of Medicine, University Clermont-Auvergne, 28 place Henri Dunant, BP 38, 63001 Clermont-Ferrand Cedex, France.

Charles I White (CI)

GReD Institute, CNRS UMR6293, INSERM U1103, Faculty of Medicine, University Clermont-Auvergne, 28 place Henri Dunant, BP 38, 63001 Clermont-Ferrand Cedex, France.

Michel Charbonneau (M)

GReD Institute, CNRS UMR6293, INSERM U1103, Faculty of Medicine, University Clermont-Auvergne, 28 place Henri Dunant, BP 38, 63001 Clermont-Ferrand Cedex, France. Electronic address: michel.charbonneau@uca.fr.

Articles similaires

Membrane potential stimulates ADP import and ATP export by the mitochondrial ADP/ATP carrier due to its positively charged binding site.

Vasiliki Mavridou, Martin S King, Andre Bazzone et al.
1.00
Adenosine Triphosphate Adenosine Diphosphate Mitochondrial ADP, ATP Translocases Binding Sites Mitochondria

Reprogramming cellular senescence in the tumor microenvironment augments cancer immunotherapy through multifunctional nanocrystals.

Zheng Wang, Yinglu Chen, Hui Fang et al.
1.00
Tumor Microenvironment Nanoparticles Immunotherapy Cellular Senescence Animals

Saccharomyces cerevisiae whole cell biotransformation for the production of aldehyde flavors and fragrances.

Nazreen V M Abdul Muthaliff, Yao Zong Ng, Wei Mei Guo et al.
1.00
Saccharomyces cerevisiae Aldehydes Biotransformation Flavoring Agents Lipoxygenase

The dual life of disordered lysine-rich domains of snoRNPs in rRNA modification and nucleolar compaction.

Carine Dominique, Nana Kadidia Maiga, Alfonso Méndez-Godoy et al.
1.00
Saccharomyces cerevisiae Lysine Cell Nucleolus RNA, Ribosomal Saccharomyces cerevisiae Proteins

Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › Inhibition of the alternative lengthening of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines des groupes de complémentation de l'anémie de Fanconi › Rad51 Recombinase › Inhibition of the alternative lengthening of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Protéine Rad52 de réparation-recombinaison de l'ADN › Inhibition of the alternative lengthening of...
questionsmedicales.fr › Phénomènes génétiques › Recombinaison génétique › Inhibition of the alternative lengthening of...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Séquences d'acides nucléiques régulatrices › Inhibition of the alternative lengthening of...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Inhibition of the alternative lengthening of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › Inhibition of the alternative lengthening of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Ribonucléoprotéines › Telomerase › Inhibition of the alternative lengthening of...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Télomère › Inhibition of the alternative lengthening of...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Division cellulaire › Homéostasie des télomères › Inhibition of the alternative lengthening of...