Characterization of excipient enhanced growth (EEG) tobramycin dry powder aerosol formulations.

Administration, Inhalation Aerosols Dry Powder Inhalers Excipients Particle Size Powders Tobramycin
Aerosol performance Dry powder aerosol Excipient enhanced growth Hygroscopic formulation L-leucine Solid-state stability Spray drying Tobramycin

Journal

International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127

Informations de publication

Date de publication:
15 Dec 2020
Historique:
received: 17 09 2020
revised: 20 10 2020
accepted: 25 10 2020
pubmed: 2 11 2020
medline: 22 6 2021
entrez: 1 11 2020
Statut: ppublish

Résumé

Spray drying can be utilized to produce highly dispersible powder aerosol formulations. However, these formulations are known to be hygroscopic, leading to potential solid-state stability and aerosol performance issues. This study aims to investigate if control of the spray drying particle formation conditions could be employed to improve the solid-state stability and alter the aerosol performance of tobramycin EEG formulations. Eight formulations were prepared, each had the same drug:excipient ratio of 60%

Identifiants

DOI: 10.1016/j.ijpharm.2020.120027 PMID: 33130220 PMC: PMC8040971
pubmed: 33130220
pii: S0378-5173(20)31012-7
doi: 10.1016/j.ijpharm.2020.120027
pmc: PMC8040971
mid: NIHMS1644157
pii:
doi:

Substances chimiques

Aerosols 0
Excipients 0
Powders 0
Tobramycin VZ8RRZ51VK

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

120027

Subventions

Organisme : NICHD NIH HHS
ID : R01 HD087339
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139673
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

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Auteurs

Amr Hassan (A)

Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: aahassan2@vcu.edu.

Dale Farkas (D)

Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, USA.

Worth Longest (W)

Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, USA; Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, USA.

Michael Hindle (M)

Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, USA.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par inhalation › Characterization of excipient enhanced growth...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Aérosols › Characterization of excipient enhanced growth...
questionsmedicales.fr › Équipement et fournitures › Nébuliseurs et vaporisateurs › Inhalateurs à poudre sèche › Characterization of excipient enhanced growth...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Excipients pharmaceutiques › Excipients › Characterization of excipient enhanced growth...
questionsmedicales.fr › Phénomènes chimiques › Taille de particule › Characterization of excipient enhanced growth...
questionsmedicales.fr › Préparations pharmaceutiques › Poudres › Characterization of excipient enhanced growth...
questionsmedicales.fr › Glucides › Hétérosides › Aminosides › Kanamycine › Nébramycine › Tobramycine › Characterization of excipient enhanced growth...