Rapamycin Extends Life Span in Apc
Adenomatous Polyposis Coli Protein
/ genetics
Animals
Carcinogenesis
/ drug effects
Colon
/ drug effects
Colonic Neoplasms
/ genetics
Disease Models, Animal
Female
Heterozygote
Humans
Intestinal Mucosa
/ drug effects
Male
Mechanistic Target of Rapamycin Complex 1
/ antagonists & inhibitors
Mice
Mice, Transgenic
Sirolimus
/ pharmacology
Survival Analysis
Time Factors
Aging
Crypt stem cells
eEF2K
mTORC1
rpS6
Journal
Clinical colorectal cancer
ISSN: 1938-0674
Titre abrégé: Clin Colorectal Cancer
Pays: United States
ID NLM: 101120693
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
14
05
2020
revised:
17
07
2020
accepted:
24
08
2020
pubmed:
3
11
2020
medline:
15
12
2021
entrez:
2
11
2020
Statut:
ppublish
Résumé
We previously showed that lifelong rapamycin treatment of short-lived Apc We asked, what effect would pretreatment of Apc Forty-two ppm enteric formulation of rapamycin diet exacerbated the temporary weight loss associated with DSS treatment in both sexes. However, our survival studies showed that chronic rapamycin treatment significantly extended lifespan of Apc These data indicate that enteric rapamycin prevents or delays colon neoplasia in Apc
Sections du résumé
BACKGROUND
We previously showed that lifelong rapamycin treatment of short-lived Apc
MATERIALS AND METHODS
We asked, what effect would pretreatment of Apc
RESULTS
Forty-two ppm enteric formulation of rapamycin diet exacerbated the temporary weight loss associated with DSS treatment in both sexes. However, our survival studies showed that chronic rapamycin treatment significantly extended lifespan of Apc
CONCLUSION
These data indicate that enteric rapamycin prevents or delays colon neoplasia in Apc
Identifiants
pubmed: 33132009
pii: S1533-0028(20)30123-7
doi: 10.1016/j.clcc.2020.08.006
pmc: PMC7956131
mid: NIHMS1629484
pii:
doi:
Substances chimiques
Adenomatous Polyposis Coli Protein
0
adenomatous polyposis coli protein, mouse
0
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Sirolimus
W36ZG6FT64
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e61-e70Subventions
Organisme : NCI NIH HHS
ID : R01 CA188032
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG017242
Pays : United States
Organisme : BLRD VA
ID : I01 BX001641
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA193835
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG022307
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier Inc.
Références
Biochem Soc Trans. 2017 Feb 8;45(1):213-221
pubmed: 28202675
Nature. 2009 Jul 16;460(7253):392-5
pubmed: 19587680
Aging Cell. 2014 Jun;13(3):468-77
pubmed: 24341993
Cell Rep. 2018 Aug 28;24(9):2312-2328.e7
pubmed: 30157426
Nat Rev Mol Cell Biol. 2020 Apr;21(4):183-203
pubmed: 31937935
Aging (Albany NY). 2013 Feb;5(2):100-10
pubmed: 23454836
Nature. 2011 Jan 20;469(7330):415-8
pubmed: 21113151
Nature. 2016 May 18;534(7606):272-6
pubmed: 27279227
Aging (Albany NY). 2012 Oct;4(10):715-22
pubmed: 23117593
Science. 2015 Dec 4;350(6265):1191-3
pubmed: 26785476
Sci Transl Med. 2014 Dec 24;6(268):268ra179
pubmed: 25540326
Orphanet J Rare Dis. 2009 Oct 12;4:22
pubmed: 19822006
Oncogene. 2008 Dec;27 Suppl 2:S43-51
pubmed: 19956179
Sci Signal. 2012 Mar 27;5(217):ra24
pubmed: 22457330
J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201
pubmed: 20974732
Cancer Prev Res (Phila). 2014 Jan;7(1):169-78
pubmed: 24282255
Int J Cancer. 2006 Jan 1;118(1):25-34
pubmed: 16049979
Exp Gerontol. 2018 May;105:53-69
pubmed: 29408453
Carcinogenesis. 2010 Jan;31(1):83-9
pubmed: 19969554
Pathobiol Aging Age Relat Dis. 2016 May 27;6:31688
pubmed: 27237224
Nature. 2012 Jun 28;486(7404):490-5
pubmed: 22722868
Carcinogenesis. 2009 Feb;30(2):183-96
pubmed: 19037092
Science. 1990 Jan 19;247(4940):322-4
pubmed: 2296722
Cancer Cell. 2017 Mar 13;31(3):424-435
pubmed: 28292440
Curr Opin Cell Biol. 2011 Dec;23(6):744-55
pubmed: 21963299
Gastroenterology. 2012 May;142(5):1195-1205.e6
pubmed: 22333952
Cancer Discov. 2011 Aug;1(3):248-59
pubmed: 22140653
Target Oncol. 2009 Apr;4(2):135-42
pubmed: 19381454
Nat Rev Drug Discov. 2011 Oct 31;10(11):868-80
pubmed: 22037041
Aging Cell. 2012 Aug;11(4):675-82
pubmed: 22587563
Sci Transl Med. 2018 Jul 11;10(449):
pubmed: 29997249
Carcinogenesis. 2003 Feb;24(2):179-83
pubmed: 12584165
Nature. 2015 Jan 22;517(7535):497-500
pubmed: 25383520
Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13544-9
pubmed: 18768809
Cancer Prev Res (Phila). 2011 Jul;4(7):1011-20
pubmed: 21733825
Cancer Prev Res (Phila). 2015 May;8(5):400-9
pubmed: 25736275
J Biol Chem. 2001 Apr 6;276(14):10943-51
pubmed: 11278364