Syntheses and Evaluation of 2- or 3-(N-Cyclicamino)chromone Derivatives as Monoamine Oxidase Inhibitors.
2-(N-cycloamino)chromone
3-(N-cycloamino)chromone
molecular docking analysis
monoamine oxidase (MAO)
structure–activity relationship
Journal
Chemical & pharmaceutical bulletin
ISSN: 1347-5223
Titre abrégé: Chem Pharm Bull (Tokyo)
Pays: Japan
ID NLM: 0377775
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
2
11
2020
pubmed:
3
11
2020
medline:
6
5
2021
Statut:
ppublish
Résumé
A series of 2-(N-cyclicamino)chromone derivatives (1a-4c) and 3-(N-cyclicamino)chromone derivatives (5a-8c) were synthesized, and their monoamine oxidase (MAO) A and B inhibitory activities were studied as part of a structure-activity relationship investigation. Compounds 1a-4c showed no remarkable inhibition for MAO-A or MAO-B, whereas compounds 5a-8c (with a few exceptions) showed significant and selective inhibition of MAO-B. Of these compounds, 7c, 7-methoxy-3-(4-phenyl-1-piperazinyl)-4H-1-benzopyran-4-one inhibited MAO-B the most potently and selectively, having IC
Identifiants
pubmed: 33132375
doi: 10.1248/cpb.c20-00579
doi:
Substances chimiques
Benzopyrans
0
Chromones
0
Monoamine Oxidase Inhibitors
0
benzopyran-4-one
0
Monoamine Oxidase
EC 1.4.3.4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM