Xylose Assimilation for the Efficient Production of Biofuels and Chemicals by Engineered Saccharomyces cerevisiae.
Saccharomyces cerevisiae
co-fermentation
lignocellulosic biofuels
metabolic engineering
xylose
Journal
Biotechnology journal
ISSN: 1860-7314
Titre abrégé: Biotechnol J
Pays: Germany
ID NLM: 101265833
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
revised:
15
10
2020
received:
30
10
2020
pubmed:
3
11
2020
medline:
28
4
2021
entrez:
2
11
2020
Statut:
ppublish
Résumé
Microbial conversion of plant biomass into fuels and chemicals offers a practical solution to global concerns over limited natural resources, environmental pollution, and climate change. Pursuant to these goals, researchers have put tremendous efforts and resources toward engineering the yeast Saccharomyces cerevisiae to efficiently convert xylose, the second most abundant sugar in lignocellulosic biomass, into various fuels and chemicals. Here, recent advances in metabolic engineering of yeast is summarized to address bottlenecks on xylose assimilation and to enable simultaneous co-utilization of xylose and other substrates in lignocellulosic hydrolysates. Distinct characteristics of xylose metabolism that can be harnessed to produce advanced biofuels and chemicals are also highlighted. Although many challenges remain, recent research investments have facilitated the efficient fermentation of xylose and simultaneous co-consumption of xylose and glucose. In particular, understanding xylose-induced metabolic rewiring in engineered yeast has encouraged the use of xylose as a carbon source for producing various non-ethanol bioproducts. To boost the lignocellulosic biomass-based bioeconomy, much attention is expected to promote xylose-utilizing efficiency via reprogramming cellular regulatory networks, to attain robust co-fermentation of xylose and other cellulosic carbon sources under industrial conditions, and to exploit the advantageous traits of yeast xylose metabolism for producing diverse fuels and chemicals.
Identifiants
pubmed: 33135317
doi: 10.1002/biot.202000142
doi:
Substances chimiques
Biofuels
0
Ethanol
3K9958V90M
Xylose
A1TA934AKO
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000142Subventions
Organisme : DOE Center for Advanced Bioenergy and Bioproducts Innovation
ID : DE-SC0018420
Organisme : China Scholarship Council
ID : 201606350094
Informations de copyright
© 2020 Wiley-VCH GmbH.
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