Exploring extra dimensions to capture saliva metabolite fingerprints from metabolically healthy and unhealthy obese patients by comprehensive two-dimensional gas chromatography featuring Tandem Ionization mass spectrometry.
Acetylglucosamine
/ analysis
Algorithms
Amino Acids, Neutral
/ analysis
Chromatography
/ methods
Chromatography, Gas
/ methods
Chromatography, High Pressure Liquid
Cyclohexanes
/ chemistry
Deoxyribose
/ analysis
Esters
/ analysis
Fuzzy Logic
Gas Chromatography-Mass Spectrometry
/ methods
Glucuronates
/ analysis
Humans
Lactose
/ analysis
Male
N-Acetylneuraminic Acid
/ analysis
Obesity
/ metabolism
Reference Values
Saliva
/ metabolism
Solvents
Spectrometry, Mass, Electrospray Ionization
/ methods
Urea
/ analysis
Comprehensive two-dimensional gas chromatography-time of flight mass spectrometry
Fused data from multiplexed ionization
Saliva metabolome
Untargeted fingerprinting by template matching
Variable ionization energy
Journal
Analytical and bioanalytical chemistry
ISSN: 1618-2650
Titre abrégé: Anal Bioanal Chem
Pays: Germany
ID NLM: 101134327
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
03
08
2020
accepted:
13
10
2020
revised:
01
10
2020
pubmed:
4
11
2020
medline:
7
9
2021
entrez:
3
11
2020
Statut:
ppublish
Résumé
This study examines the information potential of comprehensive two-dimensional gas chromatography combined with time-of-flight mass spectrometry (GC×GC-TOF MS) and variable ionization energy (i.e., Tandem Ionization™) to study changes in saliva metabolic signatures from a small group of obese individuals. The study presents a proof of concept for an effective exploitation of the complementary nature of tandem ionization data. Samples are taken from two sub-populations of severely obese (BMI > 40 kg/m
Identifiants
pubmed: 33140127
doi: 10.1007/s00216-020-03008-6
pii: 10.1007/s00216-020-03008-6
pmc: PMC7806578
doi:
Substances chimiques
Amino Acids, Neutral
0
Cyclohexanes
0
Esters
0
Glucuronates
0
Solvents
0
glucuronolactone
32449-92-6
Cyclohexane
48K5MKG32S
Deoxyribose
533-67-5
5-aminovaleric acid
660-88-8
Urea
8W8T17847W
N-Acetylneuraminic Acid
GZP2782OP0
Lactose
J2B2A4N98G
Acetylglucosamine
V956696549
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
403-418Subventions
Organisme : ERA-NET Biomarkers for Nutrition and Health Implementing the JPI HDHL objectives
ID : Project Acronym "SALIVAGES"
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