Ethyl Pyruvate-Derived Transdifferentiation of Astrocytes to Oligodendrogenesis in Cuprizone-Induced Demyelinating Model.
Animals
Astrocytes
/ drug effects
Cell Transdifferentiation
/ drug effects
Cuprizone
/ pharmacology
Demyelinating Diseases
/ drug therapy
Disease Models, Animal
Membrane Glycoproteins
Mice
Mice, Inbred C57BL
Oligodendroglia
/ drug effects
Phagocytosis
/ drug effects
Pyruvates
/ pharmacology
Receptors, Interleukin-1
Ethyl pyruvate
astrocytes
cuprizone-induced demyelination
oligodendrogenesis
transdifferentiation
Journal
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
ISSN: 1878-7479
Titre abrégé: Neurotherapeutics
Pays: United States
ID NLM: 101290381
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
accepted:
07
10
2020
pubmed:
4
11
2020
medline:
15
12
2021
entrez:
3
11
2020
Statut:
ppublish
Résumé
Astrocytes redifferentiate into oligodendrogenesis, raising the possibility that astrocytes may be a potential target in the treatment of adult demyelinated lesion. Upon the basis of the improvement of behavior abnormality and demyelination by ethyl pyruvate (EP) treatment, we further explored whether EP affects the function of astrocytes, especially the transdifferentiation of astrocytes into oligodendrogenesis. The results showed that EP treatment increased the accumulation of astrocytes in myelin sheath and promoted the phagocytosis of myelin debris by astrocytes in vivo and in vitro. At the same time, EP treatment induced astrocytes to upregulate the expression of CNTF and BDNF in the corpus callosum and striatum as well as cultured astrocytes, accompanied by increased expression of nestin, Sox2, and β-catenin and decreased expression of Notch1 by astrocytes. As a result, EP treatment effectively promoted the generation of NG2
Identifiants
pubmed: 33140235
doi: 10.1007/s13311-020-00947-x
pii: 10.1007/s13311-020-00947-x
pmc: PMC8116372
doi:
Substances chimiques
Membrane Glycoproteins
0
Pyruvates
0
Receptors, Interleukin-1
0
TIRAP protein, human
0
ethyl pyruvate
03O98E01OB
Cuprizone
5N16U7E0AO
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
488-502Subventions
Organisme : The National Natural Science Foundation of China
ID : No. 81473577
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