Amino Acid Substitution
Dose-Response Relationship, Drug
Drug Resistance, Viral
Genome, Viral
Genotype
HIV Antigens
/ genetics
HIV Infections
/ drug therapy
HIV-1
/ drug effects
Humans
Microbial Sensitivity Tests
Mutation
Phenotype
Phylogeny
Protease Inhibitors
/ pharmacology
Sequence Deletion
Viral Load
gag Gene Products, Human Immunodeficiency Virus
/ genetics
Africa
Gag
HIV
antiretroviral
antiretroviral resistance
drug
human immunodeficiency virus
protease
protease inhibitors
proteases
resistance
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
03 11 2020
03 11 2020
Historique:
entrez:
4
11
2020
pubmed:
5
11
2020
medline:
8
9
2021
Statut:
epublish
Résumé
Protease inhibitors (PIs) are the second- and last-line therapy for the majority of HIV-infected patients worldwide. Only around 20% of individuals who fail PI regimens develop major resistance mutations in protease. We sought to explore the role of mutations in
Identifiants
pubmed: 33144375
pii: mBio.02036-20
doi: 10.1128/mBio.02036-20
pmc: PMC7642677
pii:
doi:
Substances chimiques
HIV Antigens
0
Protease Inhibitors
0
gag Gene Products, Human Immunodeficiency Virus
0
p17 protein, Human Immunodeficiency Virus Type 1
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Department of Health
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI147331
Pays : United States
Organisme : Medical Research Council
ID : MR/S023380/1
Pays : United Kingdom
Organisme : PEPFAR
Pays : United States
Organisme : Wellcome Trust
ID : WT108082AIA
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Datir et al.
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