Adaptive laboratory evolution of native methanol assimilation in Saccharomyces cerevisiae.
Adaptor Proteins, Signal Transducing
/ genetics
Alcohol Dehydrogenase
/ genetics
Carbon Isotopes
Directed Molecular Evolution
/ methods
Fermentation
/ genetics
GTP-Binding Proteins
/ genetics
Industrial Microbiology
/ methods
Mass Spectrometry
Metabolic Engineering
Metabolomics
Methanol
/ metabolism
Proteome
/ metabolism
Saccharomyces cerevisiae
/ genetics
Saccharomyces cerevisiae Proteins
/ genetics
Systems Biology
/ methods
Transcription Factors
/ genetics
Transcriptome
/ genetics
Whole Genome Sequencing
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
04 11 2020
04 11 2020
Historique:
received:
31
07
2019
accepted:
05
10
2020
entrez:
5
11
2020
pubmed:
6
11
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Utilising one-carbon substrates such as carbon dioxide, methane, and methanol is vital to address the current climate crisis. Methylotrophic metabolism enables growth and energy generation from methanol, providing an alternative to sugar fermentation. Saccharomyces cerevisiae is an important industrial microorganism for which growth on one-carbon substrates would be relevant. However, its ability to metabolize methanol has been poorly characterised. Here, using adaptive laboratory evolution and
Identifiants
pubmed: 33149159
doi: 10.1038/s41467-020-19390-9
pii: 10.1038/s41467-020-19390-9
pmc: PMC7643182
doi:
Substances chimiques
ASC1 protein, S cerevisiae
0
Adaptor Proteins, Signal Transducing
0
Carbon Isotopes
0
Proteome
0
Saccharomyces cerevisiae Proteins
0
Transcription Factors
0
ADH2 protein, S cerevisiae
EC 1.1.1.1
Alcohol Dehydrogenase
EC 1.1.1.1
GTP-Binding Proteins
EC 3.6.1.-
Methanol
Y4S76JWI15
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5564Références
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