Brain pathology and cerebellar purkinje cell loss in a mouse model of chronic neuronopathic Gaucher disease.
Acid-beta glucosidase
Cerebellum
Gaucher disease (GD)
Gba(-/-);Gba(tg) mice
Neuropathology
Parkinson's disease
Purkinje neurons
Sphingolipids
Journal
Progress in neurobiology
ISSN: 1873-5118
Titre abrégé: Prog Neurobiol
Pays: England
ID NLM: 0370121
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
21
05
2020
revised:
03
10
2020
accepted:
25
10
2020
pubmed:
6
11
2020
medline:
24
12
2021
entrez:
5
11
2020
Statut:
ppublish
Résumé
Gaucher disease (GD) is currently the focus of considerable attention due primarily to the association between the gene that causes GD (GBA) and Parkinson's disease. Mouse models exist for the systemic (type 1) and for the acute neuronopathic forms (type 2) of GD. Here we report the generation of a mouse that phenotypically models chronic neuronopathic type 3 GD. Gba
Identifiants
pubmed: 33152398
pii: S0301-0082(20)30194-5
doi: 10.1016/j.pneurobio.2020.101939
pii:
doi:
Substances chimiques
Glucosylceramidase
EC 3.2.1.45
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101939Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.