Immune dyscrasia in adult growth hormone deficiency: Evaluation of hemolytic complement activity (CH50) and IgG subclasses.
Adult
Aged
Arginine
/ administration & dosage
Body Mass Index
Case-Control Studies
Complement Hemolytic Activity Assay
Complement System Proteins
/ immunology
Female
Growth Hormone-Releasing Hormone
/ administration & dosage
Human Growth Hormone
/ deficiency
Humans
Immunoglobulin G
/ immunology
Male
Middle Aged
CH50
Free light chains
GHD
Immunoglobulins
Low grade chronic inflammation
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
22
07
2020
revised:
06
09
2020
accepted:
11
09
2020
entrez:
6
11
2020
pubmed:
7
11
2020
medline:
20
2
2021
Statut:
ppublish
Résumé
CH50 is a screening assay for the activation of the classical complement pathway, the immunoglobulins-mediated one, activated in several inflammatory diseases. Adult growth hormone deficiency (aGHD) is recognized as a chronic inflammatory condition, although poorly evaluated under the profile of inflammatory biomarkers. The aim of this case-control observational study is to analyze CH50 and immunoglobulins G (IgG) subclasses production in aGHD, comparing this condition to healthy controls. 38 subjects were included and divided as follows: aGHD (n = 18, 6 females and 12 males); healthy controls (n = 20, 10 females and 10 males). GHD was diagnosed with dynamic test using Growth Hormone-Releasing Hormone (GHRH 50 μg i.v. + arginine 0,5 g/Kg), with a peak GH response < 9 μg/L when BMI was <30 kg/m
Identifiants
pubmed: 33152922
pii: S0753-3322(20)30950-1
doi: 10.1016/j.biopha.2020.110757
pii:
doi:
Substances chimiques
Immunoglobulin G
0
Human Growth Hormone
12629-01-5
Complement System Proteins
9007-36-7
Growth Hormone-Releasing Hormone
9034-39-3
Arginine
94ZLA3W45F
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
110757Informations de copyright
Copyright © 2020. Published by Elsevier Masson SAS.