Eosinophils Protect Mice From Angiotensin-II Perfusion-Induced Abdominal Aortic Aneurysm.
Adoptive Transfer
Aged
Angiotensin II
Animals
Aorta, Abdominal
/ metabolism
Aortic Aneurysm, Abdominal
/ chemically induced
Cells, Cultured
Dilatation, Pathologic
Disease Models, Animal
Eosinophils
/ metabolism
Female
Humans
Inflammation Mediators
/ metabolism
Interleukin-10
/ genetics
Interleukin-4
/ genetics
Macrophages
/ metabolism
Male
Mice, Inbred C57BL
Mice, Knockout, ApoE
Monocytes
/ metabolism
NF-kappa B
/ metabolism
Phenotype
Ribonucleases
/ metabolism
Vascular Remodeling
cardiovascular disease
eosinophil
inflammation
interleukin
monocyte
Journal
Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103
Informations de publication
Date de publication:
22 01 2021
22 01 2021
Historique:
pubmed:
7
11
2020
medline:
27
7
2021
entrez:
6
11
2020
Statut:
ppublish
Résumé
Blood eosinophil count and ECP (eosinophil cationic protein) associate with human cardiovascular diseases. Yet, whether eosinophils play a role in cardiovascular disease remains untested. The current study detected eosinophil accumulation in human and murine abdominal aortic aneurysm (AAA) lesions, suggesting eosinophil participation in this aortic disease. To test whether and how eosinophils affect AAA growth. Population-based randomized clinically controlled screening trials revealed higher blood eosinophil count in 579 male patients with AAA than in 5063 non-AAA control (0.236±0.182 versus 0.211±0.154, 10 Eosinophils play a protective role in AAA by releasing IL4 and cationic proteins such as mEar1 to regulate macrophage and monocyte polarization and to block NF-κB activation in aortic inflammatory and vascular cells.
Identifiants
pubmed: 33153394
doi: 10.1161/CIRCRESAHA.120.318182
pmc: PMC7855167
mid: NIHMS1644920
doi:
Substances chimiques
IL10 protein, mouse
0
Il4 protein, mouse
0
Inflammation Mediators
0
NF-kappa B
0
Angiotensin II
11128-99-7
Interleukin-10
130068-27-8
Interleukin-4
207137-56-2
Ear1 protein, mouse
EC 3.1.-
Ribonucleases
EC 3.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
188-202Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL151627
Pays : United States
Organisme : NHLBI NIH HHS
ID : R37 HL034636
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL060942
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL034636
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL080472
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL123568
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG063839
Pays : United States
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