Impact of concurrent diabetes on periodontal health in patients with acromegaly.
Acromegaly
/ blood
Adult
Diabetes Mellitus, Type 2
/ blood
Female
Follicle Stimulating Hormone
/ blood
Glycated Hemoglobin
/ metabolism
Human Growth Hormone
/ blood
Humans
Insulin-Like Growth Factor I
/ metabolism
Interleukin-6
/ blood
Luteinizing Hormone
/ blood
Magnetic Resonance Imaging
Male
Middle Aged
Oral Health
Pituitary Gland
/ diagnostic imaging
Platelet-Derived Growth Factor
/ metabolism
Prolactin
/ blood
Transforming Growth Factor beta1
/ blood
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
05 11 2020
05 11 2020
Historique:
received:
12
04
2020
accepted:
23
10
2020
entrez:
6
11
2020
pubmed:
7
11
2020
medline:
9
3
2021
Statut:
epublish
Résumé
Previous studies have suggested excess GH/IGF1 secretion in patients with acromegaly is protective for periodontal health. Diabetes is prevalent comorbidity in patients of acromegaly and is associated with worsening of periodontal disease. The present study evaluates the periodontal health and cytokines status in treatment-naive active acromegaly patients with and without diabetes. Eleven patients, each of acromegaly with and without diabetes and 20 healthy controls were enrolled. Periodontal parameters were assessed. GCF and blood samples for IL-6, TGF-β1, and PDGF were obtained. Serum GH, IGF1, HbA1c, pituitary hormones and MRI sella were performed in patients with acromegaly. There was no significant difference in periodontal status of patients with acromegaly and healthy controls. However, a significant increase in serum IL-6 (p = 0.019) and TGF-β1 (p = 0.025) levels in patients with acromegaly was observed and all patients had concurrent hypogonadism. Nevertheless, the patients with acromegaly having diabetes had modestly higher CAL and PD and serum IL-6 levels (p = 0.051), but it could not exert adverse effects on periodontal health in presence of GH/IGF1 excess. GH/IGF1 excess did not exert a protective effect on periodontal status in acromegaly, possibly due to concurrent hypogonadism and opposing cytokines; however, it could mask the ill-effects of diabetes on periodontal health.
Identifiants
pubmed: 33154456
doi: 10.1038/s41598-020-76067-5
pii: 10.1038/s41598-020-76067-5
pmc: PMC7645583
doi:
Substances chimiques
Glycated Hemoglobin A
0
Interleukin-6
0
Platelet-Derived Growth Factor
0
Transforming Growth Factor beta1
0
hemoglobin A1c protein, human
0
platelet-derived growth factor A
0
Human Growth Hormone
12629-01-5
Insulin-Like Growth Factor I
67763-96-6
Prolactin
9002-62-4
Luteinizing Hormone
9002-67-9
Follicle Stimulating Hormone
9002-68-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19170Références
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