Burkholderia pseudomallei Clinical Isolates Are Highly Susceptible
AMR
Burkholderia pseudomallei
MIC
antimicrobial resistance
cefiderocol
melioidosis
minimum inhibitory concentration
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
20 01 2021
20 01 2021
Historique:
received:
09
04
2020
accepted:
22
10
2020
pubmed:
11
11
2020
medline:
22
6
2021
entrez:
10
11
2020
Statut:
epublish
Résumé
Cefiderocol is a cephalosporin designed to treat multidrug-resistant Gram-negative infections. By forming a chelated complex with ferric iron, cefiderocol is transported into the periplasmic space via bacterial iron transport systems and primarily binds to penicillin-binding protein 3 (PBP3) to inhibit peptidoglycan synthesis. This mode of action results in cefiderocol having greater
Identifiants
pubmed: 33168603
pii: AAC.00685-20
doi: 10.1128/AAC.00685-20
pmc: PMC7848980
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Cephalosporins
0
Siderophores
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Crown copyright 2021.
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