The global impact of SARS-CoV-2 in 181 people with cystic fibrosis.
Adult
Age Factors
Aged
COVID-19
/ epidemiology
COVID-19 Testing
/ methods
Comorbidity
Cystic Fibrosis
/ epidemiology
Female
Global Health
Hospitalization
/ statistics & numerical data
Humans
Lung
/ diagnostic imaging
Lung Transplantation
/ statistics & numerical data
Male
Mortality
Outcome Assessment, Health Care
Registries
/ statistics & numerical data
Respiratory Function Tests
/ methods
Risk Factors
SARS-CoV-2
/ isolation & purification
Sex Factors
Tomography, X-Ray Computed
/ methods
COVID-19
Coronavirus
Cystic fibrosis
SARS-CoV-2
Transplant
Journal
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
ISSN: 1873-5010
Titre abrégé: J Cyst Fibros
Pays: Netherlands
ID NLM: 101128966
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
14
09
2020
revised:
21
10
2020
accepted:
23
10
2020
pubmed:
14
11
2020
medline:
31
12
2020
entrez:
13
11
2020
Statut:
ppublish
Résumé
With the growing SARS-CoV-2 pandemic, we need to better understand its impact in specific patient groups like those with Cystic Fibrosis (CF). We report on 181 people with CF (32 post-transplant) from 19 countries diagnosed with SARS-CoV-2 prior to 13 June 2020. Infection with SARS-CoV-2 appears to exhibit a similar spectrum of outcomes to that seen in the general population, with 11 people admitted to intensive care (7 post-transplant), and 7 deaths (3 post-transplant). A more severe clinical course may be associated with older age, CF-related diabetes, lower lung function in the year prior to infection, and having received an organ transplant. Whilst outcomes in this large cohort are better than initially feared overall, possibly due to a protective effect of the relatively younger age of the CF population compared to other chronic conditions, SARS-CoV-2 is not a benign disease for all people in this patient group.
Identifiants
pubmed: 33183965
pii: S1569-1993(20)30877-8
doi: 10.1016/j.jcf.2020.10.003
pmc: PMC7641525
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
868-871Investigateurs
Scott C Bell
(SC)
David Reid
(D)
Peter Wark
(P)
Eva Van Braeckel
(EV)
Sophie Gohy
(S)
Christiane Knoop
(C)
Jessica Pirson
(J)
Elke De Wachter
(E)
Lieven Dupont
(L)
Laurence Hanssens
(L)
Vicky Nowé
(V)
Monique Lequesne
(M)
Rodrigo A Athanazio
(RA)
Daniela G Meneses
(DG)
Véronique Boussaud
(V)
Graziella Brinchault
(G)
Emmanuelle Coirier-Duet
(E)
Jean-Christophe Dubus
(JC)
Dominique Grenet
(D)
Sandra de Miranda
(S)
Laurence Beaumont
(L)
Reem Kanaan
(R)
Muriel Lauraens
(M)
Clémence Martin
(C)
Marie Mittaine Martin
(MM)
Anne Prévotat
(A)
Martine Reynaud-Gaubert
(M)
Isabelle Sermet-Gaudelus
(I)
Aurelie Tatopoulos
(A)
Raphael Chiron
(R)
Marie-Laure Dalphin
(ML)
Michele Gerardin
(M)
Laurence Weiss
(L)
Nathalie Wizla
(N)
Sophie Ramel
(S)
Barry Plant
(B)
Cedric Gunaratnam
(C)
Abaigeal Jackson
(A)
Rosaria Casciaro
(R)
Francesca Lucca
(F)
Valeria Daccò
(V)
Anna Folino
(A)
Antonio Manca
(A)
Barbara Messore
(B)
Letizia Morlacchi
(L)
Giovanna Pisi
(G)
Piercarlo Poli
(P)
Annalisa Amato
(A)
Gianluca Ferrari
(G)
Karin de Winter-de Groot
(K)
Bart Luijk
(B)
Geertjan Wesseling
(G)
Elena Kondratyeva
(E)
Elena Zhekayte
(E)
Elena Amelina
(E)
Mariya Mukhina
(M)
Olga Simonova
(O)
Antonio Alvarez-Fernandez
(A)
Amparo Sole-Jover
(A)
Isidoro Cortell-Aznar
(I)
Rosa Giron-Moreno
(R)
Alejandro Lopez-Neyra
(A)
Isabel Ramos-Cancelo
(I)
Maite Lzaro-Carrasco
(M)
Marta Ruiz de Valbuena
(M)
Concepcin Prados-Sanchez
(C)
Jordi Costa-Colomer
(J)
Silvia Gartner
(S)
Layla Diab-Caceres
(L)
Marita Gilljam
(M)
Ulrika Lindberg
(U)
Stefanie Diemer
(S)
Mark Allenby
(M)
Stephen J Bourke
(S)
Susan C Charman
(S)
Janet Collinson
(J)
Owen Dempsey
(O)
Sarah Denniston
(S)
Maya Desai
(M)
Jamie Duckers
(J)
Christine Etherington
(C)
Elaine Gunn
(E)
Alex Higton
(A)
Timothy Ho
(T)
Jeremy Hull
(J)
Andrew Jones
(A)
Robert Ian Ketchell
(R)
Susan L Madge
(SL)
Anirban Maitra
(A)
Ghulam Mujtaba
(G)
Edward Nash
(E)
Dilip Nazareth
(D)
Christopher OBrien
(C)
Claire Onyon
(C)
Christopher Orchard
(C)
Daniel Peckham
(D)
Helen Rodgers
(H)
Nadia Shafi
(N)
Nicholas Simmonds
(N)
Kevin Southern
(K)
Martin Walshaw
(M)
Danie Watson
(D)
Joanna L Whitehouse
(J)
Informations de copyright
Copyright © 2020 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have no conflicts of interest to declare relating to this work.