Challenges and future directions in LC-MS-based multiclass method development for the quantification of food contaminants.
Contaminants
Food safety
HRMS
MS/MS
Multiclass
Residues
Journal
Analytical and bioanalytical chemistry
ISSN: 1618-2650
Titre abrégé: Anal Bioanal Chem
Pays: Germany
ID NLM: 101134327
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
26
08
2020
accepted:
15
10
2020
revised:
01
10
2020
pubmed:
15
11
2020
medline:
22
6
2021
entrez:
14
11
2020
Statut:
ppublish
Résumé
Monitoring of food contaminants and residues has undergone a significant improvement in recent years and is now performed in an intensive manner. Achievements in the area of chromatography-mass spectrometry coupling techniques enabled the development of quantitative multi-target approaches covering several hundred analytes. Although the majority of methods are focusing on the analysis of one specific group of substances, such as pesticides, mycotoxins, or veterinary drugs, current trends are going towards the simultaneous determination of multiclass compounds from several families of contaminants and residues. This work provides an overview of relevant multiclass concepts based on LC-MS/MS and LC-HRMS instruments. Merits and shortcomings will be critically discussed based on current performance characteristics of the EU legislation system. In addition, the discussion of a recently developed multiclass approach covering >1000 substances is presented as a case study to illustrate the current developments in this area.
Identifiants
pubmed: 33188454
doi: 10.1007/s00216-020-03015-7
pii: 10.1007/s00216-020-03015-7
pmc: PMC7801304
doi:
Substances chimiques
Mycotoxins
0
Pesticides
0
Veterinary Drugs
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
25-34Subventions
Organisme : Österreichische Forschungsförderungsgesellschaft
ID : 854182
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