Oxytocin in the Male Reproductive Tract; The Therapeutic Potential of Oxytocin-Agonists and-Antagonists.
epididymis
male reproduction
oxytocin
oxytocin and arginine vasopressin crosstalk
oxytocin receptor signaling
oxytocin-agonist and antagonist
prostate
testis
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
05
2020
accepted:
07
09
2020
entrez:
16
11
2020
pubmed:
17
11
2020
medline:
22
5
2021
Statut:
epublish
Résumé
In this review, the role of oxytocin and oxytocin-like agents (acting via the oxytocin receptor and belonging to the oxytocin-family) in the male reproductive tract is considered. Previous research (dating back over 60 years) is revised and connected with recently found aspects of the role oxytocin plays in male reproductive health. The local expression of oxytocin and its receptor in the male reproductive tract of different species is summarized. Colocalization and possible crosstalk to other agents and receptors and their resulting effects are discussed. The role of the newly reported oxytocin focused signaling pathways in the male reproductive tract, other than mediating contractility, is critically examined. The structure and effect of the most promising oxytocin-agonists and -antagonists are reviewed for their potential in treating male disorders with origins in the male reproductive tract such as prostate diseases and ejaculatory disorders.
Identifiants
pubmed: 33193084
doi: 10.3389/fendo.2020.565731
pmc: PMC7642622
doi:
Substances chimiques
Hormone Antagonists
0
Receptors, Oxytocin
0
Arginine Vasopressin
113-79-1
Oxytocin
50-56-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
565731Informations de copyright
Copyright © 2020 Stadler, Whittaker, Exintaris and Middendorff.
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