Identification of Novel Yellow Fever Class II Epitopes in YF-17D Vaccinees.
Alleles
Biomarkers
CD4-Positive T-Lymphocytes
/ immunology
Epitopes
/ chemistry
Epitopes, T-Lymphocyte
/ immunology
Histocompatibility Antigens Class II
/ chemistry
Humans
Immunophenotyping
Peptides
Protein Binding
T-Cell Antigen Receptor Specificity
Vaccination
Viral Proteins
/ immunology
Yellow Fever
/ immunology
Yellow Fever Vaccine
/ immunology
Yellow fever virus
/ immunology
CD4+ T cells
T cells
epitopes
vaccination
yellow fever virus
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
12 11 2020
12 11 2020
Historique:
received:
20
09
2020
revised:
27
10
2020
accepted:
09
11
2020
entrez:
17
11
2020
pubmed:
18
11
2020
medline:
4
3
2021
Statut:
epublish
Résumé
Yellow fever virus (YFV) is a mosquito-borne member of the genus flavivirus, including other important human-pathogenic viruses, such as dengue, Japanese encephalitis, and Zika. Herein, we report identifying 129 YFV Class II epitopes in donors vaccinated with the live attenuated YFV vaccine (YFV-17D). A total of 1156 peptides predicted to bind 17 different common HLA-DRB1 allelic variants were tested using IFNγ ELISPOT assays in vitro re-stimulated peripheral blood mononuclear cells from twenty-six vaccinees. Overall, we detected responses against 215 YFV epitopes. We found that the capsid and envelope proteins, as well as the non-structural (NS) proteins NS3 and NS5, were the most targeted proteins by CD4
Identifiants
pubmed: 33198381
pii: v12111300
doi: 10.3390/v12111300
pmc: PMC7697718
pii:
doi:
Substances chimiques
Biomarkers
0
Epitopes
0
Epitopes, T-Lymphocyte
0
Histocompatibility Antigens Class II
0
Peptides
0
Viral Proteins
0
Yellow Fever Vaccine
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : HHSN272200900042C
Pays : United States
Organisme : NIH HHS
ID : HHSN27220140045C
Pays : United States
Organisme : NIH HHS
ID : 75N9301900065
Pays : United States
Organisme : NIH HHS
ID : P01AI106695
Pays : United States
Références
Expert Rev Vaccines. 2018 Jan;17(1):79-90
pubmed: 29172832
Curr Protoc Immunol. 2016 Aug 01;114:18.19.1-18.19.24
pubmed: 27479659
Nat Struct Mol Biol. 2018 Jan;25(1):13-20
pubmed: 29323278
Front Immunol. 2019 Jun 21;10:1211
pubmed: 31293563
J Infect. 2016 Jun;72(6):713-722
pubmed: 27017899
J Infect Dis. 2020 Jun 11;221(12):2026-2034
pubmed: 31545372
Virology. 2002 Feb 1;293(1):151-63
pubmed: 11853408
BMC Immunol. 2008 Jan 22;9:1
pubmed: 18211710
BMC Bioinformatics. 2010 Nov 22;11:568
pubmed: 21092157
J Travel Med. 2019 Jun 11;26(5):
pubmed: 31180486
Immunogenetics. 2011 Jun;63(6):325-35
pubmed: 21305276
PLoS Comput Biol. 2008 Apr 04;4(4):e1000048
pubmed: 18389056
PLoS Negl Trop Dis. 2018 Jan 16;12(1):e0006158
pubmed: 29338001
Sci Rep. 2017 Aug 21;7(1):8907
pubmed: 28827760
Front Immunol. 2019 Sep 04;10:2125
pubmed: 31552052
Ann Intern Med. 2018 Dec 4;169(11):761-765
pubmed: 30476963
Expert Rev Vaccines. 2012 Apr;11(4):427-48
pubmed: 22551029
Curr Opin Immunol. 2009 Jun;21(3):308-13
pubmed: 19520559
Immunology. 2018 Nov;155(3):331-345
pubmed: 30014462
Nucleic Acids Res. 2012 Jul;40(Web Server issue):W525-30
pubmed: 22610854
Front Immunol. 2017 Oct 13;8:1309
pubmed: 29081779
Front Immunol. 2019 Jul 05;10:1568
pubmed: 31333679
Nat Immunol. 2018 Nov;19(11):1189-1198
pubmed: 30333606
Trends Microbiol. 2018 Nov;26(11):913-928
pubmed: 29933925
Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3050-5
pubmed: 25713354
Sci Rep. 2017 Apr 6;7(1):662
pubmed: 28386132
J Immunol Methods. 2015 Jul;422:28-34
pubmed: 25862607
J Immunol. 2011 Oct 15;187(8):4268-79
pubmed: 21918184
Vaccine. 2008 Oct 23;26(45):5712-21
pubmed: 18762226
PLoS Negl Trop Dis. 2013;7(1):e1938
pubmed: 23383350
J Virol. 2020 May 4;94(10):
pubmed: 32132233
J Infect Dis. 2016 Oct 1;214(7):1117-24
pubmed: 27443615
Hum Immunol. 2018 Feb;79(2):87-88
pubmed: 29289740
Hum Vaccin Immunother. 2019;15(10):2295-2314
pubmed: 31589551
PLoS Comput Biol. 2017 Jan 19;13(1):e1005313
pubmed: 28103239
J Immunol. 2009 Dec 15;183(12):7919-30
pubmed: 19933869
Mem Inst Oswaldo Cruz. 2017 Jun;112(6):447-451
pubmed: 28591405
J Clin Immunol. 2009 Mar;29(2):151-7
pubmed: 19052852
Lancet Infect Dis. 2019 Dec;19(12):1363-1370
pubmed: 31543249
Clin Exp Allergy. 2016 Sep;46(9):1194-205
pubmed: 27359111
PLoS One. 2016 Mar 15;11(3):e0149871
pubmed: 26977808
J Immunol Res. 2015;2015:763461
pubmed: 26568965
Cell Mol Immunol. 2016 Jan;13(1):36-46
pubmed: 26435066
Front Immunol. 2018 Oct 01;9:2225
pubmed: 30327651
Nature. 2017 Dec 21;552(7685):362-367
pubmed: 29236685
Nucleic Acids Res. 2019 Jan 8;47(D1):D339-D343
pubmed: 30357391
Bull World Health Organ. 1981;59(6):895-900
pubmed: 6978196
J Clin Microbiol. 2018 Sep 25;56(10):
pubmed: 30021822
Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):12704-12709
pubmed: 30459272
J Virol. 2017 Nov 30;91(24):
pubmed: 28978707
J Immunol. 2013 Mar 1;190(5):2150-8
pubmed: 23338234