SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells.
Angiotensin-Converting Enzyme 2
/ analysis
Animals
COVID-19
/ complications
Cells, Cultured
Diabetes Complications
/ genetics
Diabetes Mellitus
/ genetics
Gene Expression
Humans
Insulin-Secreting Cells
/ metabolism
Mice
Microvessels
/ metabolism
Pancreas
/ metabolism
RNA, Messenger
/ analysis
SARS-CoV-2
/ physiology
Serine Endopeptidases
/ analysis
Virus Internalization
ACE2
COVID-19
SARS-CoV-2
TMPRSS2
beta cell
duct
islet
microvasculature
pancreas
pericyte
Journal
Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170
Informations de publication
Date de publication:
01 12 2020
01 12 2020
Historique:
received:
01
09
2020
revised:
19
10
2020
accepted:
10
11
2020
pubmed:
19
11
2020
medline:
18
12
2020
entrez:
18
11
2020
Statut:
ppublish
Résumé
Isolated reports of new-onset diabetes in individuals with COVID-19 have led to the hypothesis that SARS-CoV-2 is directly cytotoxic to pancreatic islet β cells. This would require binding and entry of SARS-CoV-2 into β cells via co-expression of its canonical cell entry factors, angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2); however, their expression in human pancreas has not been clearly defined. We analyzed six transcriptional datasets of primary human islet cells and found that ACE2 and TMPRSS2 were not co-expressed in single β cells. In pancreatic sections, ACE2 and TMPRSS2 protein was not detected in β cells from donors with and without diabetes. Instead, ACE2 protein was expressed in islet and exocrine tissue microvasculature and in a subset of pancreatic ducts, whereas TMPRSS2 protein was restricted to ductal cells. These findings reduce the likelihood that SARS-CoV-2 directly infects β cells in vivo through ACE2 and TMPRSS2.
Identifiants
pubmed: 33207245
pii: S1550-4131(20)30601-X
doi: 10.1016/j.cmet.2020.11.006
pmc: PMC7664344
pii:
doi:
Substances chimiques
RNA, Messenger
0
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Serine Endopeptidases
EC 3.4.21.-
TMPRSS2 protein, human
EC 3.4.21.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1028-1040.e4Subventions
Organisme : NIDDK NIH HHS
ID : UC4 DK104211
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK112232
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK089572
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK123594
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK123743
Pays : United States
Organisme : NIDDK NIH HHS
ID : R24 DK106755
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK117147
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK123716
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK098085
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK108120
Pays : United States
Organisme : NIDDK NIH HHS
ID : U2C DK059637
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK098085
Pays : United States
Organisme : Doris Duke Charitable Foundation
ID : 2020063
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL075462
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA068485
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
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