Molecular dynamic simulations of diacridine binding to DNA: Indications that C6 diacridine can bisintercalate spanning two base pairs.
9-aminoacridine
DNA binding
bisintercalation
diacridine
molecular dynamics
neighbor exclusion
Journal
Biopolymers
ISSN: 1097-0282
Titre abrégé: Biopolymers
Pays: United States
ID NLM: 0372525
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
revised:
27
10
2020
received:
20
07
2020
accepted:
03
11
2020
pubmed:
19
11
2020
medline:
15
12
2021
entrez:
18
11
2020
Statut:
ppublish
Résumé
Dimers of 9-aminoacridine linked via the 9-amino group with polymethylene chains, termed diacridines, are known to bisintercalate into DNA when the linker comprises 6 or more methylene units. There are no literature reports of crystal or NMR solution structures for bisintercalated diacridine-DNA complexes, and the issue of the structure of the C6 ([CH
Substances chimiques
Intercalating Agents
0
Aminacrine
78OY3Z0P7Z
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e23409Informations de copyright
© 2020 Wiley Periodicals LLC.
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