Acute exercise impacts AhR and PD-1 levels of CD8
Adult
Basic Helix-Loop-Helix Transcription Factors
/ metabolism
CD8-Positive T-Lymphocytes
/ metabolism
Cross-Over Studies
Exercise
/ physiology
Humans
Male
Physical Endurance
/ physiology
Programmed Cell Death 1 Receptor
/ metabolism
Receptors, Aryl Hydrocarbon
/ metabolism
Resistance Training
/ methods
Signal Transduction
/ physiology
Young Adult
Acute exercise
AhR
Kynurenine
PD-1
T-cell
Journal
European journal of applied physiology
ISSN: 1439-6327
Titre abrégé: Eur J Appl Physiol
Pays: Germany
ID NLM: 100954790
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
19
06
2020
accepted:
04
11
2020
pubmed:
20
11
2020
medline:
5
10
2021
entrez:
19
11
2020
Statut:
ppublish
Résumé
The programmed cell death protein 1 (PD-1) has become a promising target in cancer immunotherapy. PD-1 expression of CD8 In this study, 24 healthy males (age: 24.6 ± 3.9 years; weight 83.9 ± 10.5 kg; height: 182.4 ± 6.2 cm) completed a single bout of endurance (EE) and resistance exercise (RE) in a randomly assigned order on separate days. Blood samples were drawn before (t0), after (t1), and 1 h after (t2) both conditions. T-cell populations, the level of cytoplasmic AhR, and surface PD-1 were assessed by flow cytometry. T-cell populations changed over time, indicated by an increase in the absolute numbers of CD3 We analyzed the level of surface PD-1 and cytoplasmic AhR following acute physical exercise for the first time. Especially EE was observed to impact both AhR and PD-1 levels, undermining its role as the AhR-PD-1 axis modulator. These results provide new insights into the impact of exercise on AhR-signaling, which could potentially be relevant for various chronic diseases.
Identifiants
pubmed: 33211154
doi: 10.1007/s00421-020-04552-w
pii: 10.1007/s00421-020-04552-w
pmc: PMC7862188
doi:
Substances chimiques
AHR protein, human
0
Basic Helix-Loop-Helix Transcription Factors
0
PDCD1 protein, human
0
Programmed Cell Death 1 Receptor
0
Receptors, Aryl Hydrocarbon
0
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
637-644Références
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