Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia.
frontotemporal dementia (FTD)
functional magnetic resonance imaging (fMRI)
network connectivity
presymptomatic
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
revised:
07
09
2020
received:
25
09
2019
accepted:
12
09
2020
pubmed:
21
11
2020
medline:
5
11
2021
entrez:
20
11
2020
Statut:
ppublish
Résumé
The presymptomatic phase of neurodegenerative disease can last many years, with sustained cognitive function despite progressive atrophy. We investigate this phenomenon in familial frontotemporal dementia (FTD). We studied 121 presymptomatic FTD mutation carriers and 134 family members without mutations, using multivariate data-driven approach to link cognitive performance with both structural and functional magnetic resonance imaging. Atrophy and brain network connectivity were compared between groups, in relation to the time from expected symptom onset. There were group differences in brain structure and function, in the absence of differences in cognitive performance. Specifically, we identified behaviorally relevant structural and functional network differences. Structure-function relationships were similar in both groups, but coupling between functional connectivity and cognition was stronger for carriers than for non-carriers, and increased with proximity to the expected onset of disease. Our findings suggest that the maintenance of functional network connectivity enables carriers to maintain cognitive performance.
Identifiants
pubmed: 33215845
doi: 10.1002/alz.12209
pmc: PMC7611220
mid: EMS96578
doi:
Substances chimiques
C9orf72 Protein
0
MAPT protein, human
0
tau Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
500-514Subventions
Organisme : Medical Research Council
ID : MC_UU_00005/12
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00024/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M008525/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M023664/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T046015/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 103838
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J009482/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U105597119
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Investigateurs
Sónia Afonso
(S)
Maria Rosario Almeida
(MR)
Sarah Anderl-Straub
(S)
Christin Andersson
(C)
Anna Antonell
(A)
Silvana Archetti
(S)
Andrea Arighi
(A)
Mircea Balasa
(M)
Myriam Barandiaran
(M)
Nuria Bargalló
(N)
Robart Bartha
(R)
Benjamin Bender
(B)
Luisa Benussi
(L)
Valentina Bessi
(V)
Giuliano Binetti
(G)
Sandra Black
(S)
Martina Bocchetta
(M)
Sergi Borrego-Ecija
(S)
Jose Bras
(J)
Rose Bruffaerts
(R)
Paola Caroppo
(P)
David Cash
(D)
Miguel Castelo-Branco
(M)
Rhian Convery
(R)
Thomas Cope
(T)
Maura Cosseddu
(M)
María de Arriba
(M)
Giuseppe Di Fede
(G)
Zigor Díaz
(Z)
Katrina M Moore
(KM)
Diana Duro
(D)
Chiara Fenoglio
(C)
Camilla Ferrari
(C)
Carlos Ferreira
(C)
Catarina B Ferreira
(CB)
Toby Flanagan
(T)
Nick Fox
(N)
Morris Freedman
(M)
Giorgio Fumagalli
(G)
Alazne Gabilondo
(A)
Roberto Gasparotti
(R)
Serge Gauthier
(S)
Stefano Gazzina
(S)
Giorgio Giaccone
(G)
Ana Gorostidi
(A)
Caroline Greaves
(C)
Rita Guerreiro
(R)
Carolin Heller
(C)
Tobias Hoegen
(T)
Begoña Indakoetxea
(B)
Vesna Jelic
(V)
Lize Jiskoot
(L)
Hans-Otto Karnath
(HO)
Karolinska Institutet
(K)
Ron Keren
(R)
Tobias Langheinrich
(T)
Maria João Leitão
(MJ)
Albert Lladó
(A)
Gemma Lombardi
(G)
Sandra Loosli
(S)
Carolina Maruta
(C)
Simon Mead
(S)
Lieke Meeter
(L)
Gabriel Miltenberger
(G)
Rick van Minkelen
(R)
Sara Mitchell
(S)
Benedetta Nacmias
(B)
Mollie Neason
(M)
Jennifer Nicholas
(J)
Jaume Olives
(J)
Alessandro Padovani
(A)
Jessica Panman
(J)
Janne Papma
(J)
Irene Piaceri
(I)
Michela Pievani
(M)
Yolande Pijnenburg
(Y)
Cristina Polito
(C)
Enrico Premi
(E)
Sara Prioni
(S)
Catharina Prix
(C)
Rosa Rademakers
(R)
Veronica Redaelli
(V)
Tim Rittman
(T)
Ekaterina Rogaeva
(E)
Pedro Rosa-Neto
(P)
Giacomina Rossi
(G)
Martin Rossor
(M)
Beatriz Santiago
(B)
Elio Scarpini
(E)
Sonja Schönecker
(S)
Elisa Semler
(E)
Rachelle Shafei
(R)
Christen Shoesmith
(C)
Miguel Tábuas-Pereira
(M)
Mikel Tainta
(M)
Ricardo Taipa
(R)
David Tang-Wai
(D)
David L Thomas
(DL)
Paul Thompson
(P)
Hakan Thonberg
(H)
Carolyn Timberlake
(C)
Pietro Tiraboschi
(P)
Philip Vandamme
(P)
Mathieu Vandenbulcke
(M)
Michele Veldsman
(M)
Ana Verdelho
(A)
Jorge Villanua
(J)
Jason Warren
(J)
Carlo Wilke
(C)
Ione Woollacott
(I)
Elisabeth Wlasich
(E)
Henrik Zetterberg
(H)
Miren Zulaica
(M)
Informations de copyright
© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.
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