Effect of Vitamin B Complex Treatment on Macrophages to Schwann Cells Association during Neuroinflammation after Peripheral Nerve Injury.
Animals
Anti-Inflammatory Agents
/ pharmacology
Cell Communication
/ drug effects
Femoral Nerve
/ drug effects
GAP-43 Protein
Inflammation
/ pathology
Inflammation Mediators
/ metabolism
Interleukin-10
/ pharmacology
Macrophages
/ drug effects
Male
Peripheral Nerve Injuries
/ pathology
Rats
Recovery of Function
/ drug effects
Schwann Cells
/ drug effects
Tumor Necrosis Factor-alpha
/ metabolism
Vitamin B Complex
/ administration & dosage
Schwann cells
macrophages
neuroinflammation
peripheral nerve injury
vitamin B complex
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
19 Nov 2020
19 Nov 2020
Historique:
received:
17
09
2020
revised:
05
11
2020
accepted:
06
11
2020
entrez:
24
11
2020
pubmed:
25
11
2020
medline:
7
4
2021
Statut:
epublish
Résumé
Peripheral nerve injury (PNI) triggers a complex multi-cellular response involving the injured neurons, Schwann cells (SCs), and immune cells, often resulting in poor functional recovery. The aim of this study was to investigate the effects of the treatment with vitamin B (B1, B2, B3, B5, B6, and B12) complex on the interaction between macrophages and SCs during the recovery period after PNI. Transection of the motor branch of the femoral nerve followed by reconstruction by termino-terminal anastomosis was used as an experimental model. Isolated nerves from the sham (S), operated (O), and operated groups treated with the B vitamins (OT group) were used for immunofluorescence analysis. The obtained data indicated that PNI modulates interactions between macrophages and SCs in a time-dependent manner. The treatment with B vitamins complex promoted the M1-to M2-macrophage polarization and accelerated the transition from the non-myelin to myelin-forming SCs, an indicative of SCs maturation. The effect of B vitamins complex on both cell types was accompanied with an increase in macrophage/SC interactions, all of which correlated with the regeneration of the injured nerve. Clearly, the capacity of B vitamins to modulate macrophages-SCs interaction may be promising for the treatment of PNI.
Identifiants
pubmed: 33228193
pii: molecules25225426
doi: 10.3390/molecules25225426
pmc: PMC7699497
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
GAP-43 Protein
0
Inflammation Mediators
0
Tumor Necrosis Factor-alpha
0
Vitamin B Complex
12001-76-2
Interleukin-10
130068-27-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
ID : 451-03-68/2020-14/200178
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