Sigma Factor Modulation for Cyanobacterial Metabolic Engineering.
cyanobacteria
glycogen
metabolic engineering
sigma factor
Journal
Trends in microbiology
ISSN: 1878-4380
Titre abrégé: Trends Microbiol
Pays: England
ID NLM: 9310916
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
07
06
2020
revised:
25
10
2020
accepted:
26
10
2020
pubmed:
25
11
2020
medline:
21
8
2021
entrez:
24
11
2020
Statut:
ppublish
Résumé
Sigma (σ) factors are key regulatory proteins that control the transcription initiation in prokaryotes. In response to environmental or developmental cues, σ factors initiate the transcription of necessary genes responsible for maintaining a life-sustaining metabolic balance. Due to the significant role of σ factors in bacterial metabolism, their rational engineering for commercial metabolite production in photoautotrophic, cyanobacterial cells is a desirable venture. As cyanobacterial genomes typically encode multiple σ factors, effective execution of metabolic engineering efforts largely relies on uncovering the complicated gene regulatory network and further characterization of the members of σ factor regulatory circuits. This review outlines the prospects of σ factor in metabolic engineering of cyanobacteria, summarizes the challenges in the path towards an efficient strain construction and highlights the genomic context of putative regulators of cyanobacterial σ factors.
Identifiants
pubmed: 33229204
pii: S0966-842X(20)30275-4
doi: 10.1016/j.tim.2020.10.012
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Sigma Factor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
266-277Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.