Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
18 12 2020
18 12 2020
Historique:
received:
20
05
2020
accepted:
23
10
2020
pubmed:
28
11
2020
medline:
9
2
2021
entrez:
27
11
2020
Statut:
ppublish
Résumé
Spliceosome activation involves extensive protein and RNA rearrangements that lead to formation of a catalytically active U2/U6 RNA structure. At present, little is known about the assembly pathway of the latter and the mechanism whereby proteins aid its proper folding. Here, we report the cryo-electron microscopy structures of two human, activated spliceosome precursors (that is, pre-B
Identifiants
pubmed: 33243851
pii: science.abc3753
doi: 10.1126/science.abc3753
pii:
doi:
Substances chimiques
PRPF8 protein, human
0
RNA, Catalytic
0
RNA, Small Nuclear
0
RNA-Binding Proteins
0
U2 small nuclear RNA
0
U6 small nuclear RNA
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.