Childhood trauma, brain structure and emotion recognition in patients with schizophrenia and healthy participants.
Adult
Adult Survivors of Child Abuse
/ psychology
Amygdala
/ diagnostic imaging
Emotions
/ physiology
Facial Recognition
/ physiology
Female
Gyrus Cinguli
/ diagnostic imaging
Healthy Volunteers
Hippocampus
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Organ Size
/ physiology
Schizophrenia
/ diagnostic imaging
Schizophrenic Psychology
Social Perception
brain structure
childhood trauma
emotion recognition
schizophrenia
social cognition
Journal
Social cognitive and affective neuroscience
ISSN: 1749-5024
Titre abrégé: Soc Cogn Affect Neurosci
Pays: England
ID NLM: 101288795
Informations de publication
Date de publication:
24 12 2020
24 12 2020
Historique:
received:
07
04
2020
revised:
25
09
2020
accepted:
26
11
2020
pubmed:
28
11
2020
medline:
24
6
2021
entrez:
27
11
2020
Statut:
ppublish
Résumé
Childhood trauma, and in particular physical neglect, has been repeatedly associated with lower performance on measures of social cognition (e.g. emotion recognition tasks) in both psychiatric and non-clinical populations. The neural mechanisms underpinning this association have remained unclear. Here, we investigated whether volumetric changes in three stress-sensitive regions-the amygdala, hippocampus and anterior cingulate cortex (ACC)-mediate the association between childhood trauma and emotion recognition in a healthy participant sample (N = 112) and a clinical sample of patients with schizophrenia (N = 46). Direct effects of childhood trauma, specifically physical neglect, on Emotion Recognition Task were observed in the whole sample. In healthy participants, reduced total and left ACC volumes were observed to fully mediate the association between both physical neglect and total childhood trauma score, and emotion recognition. No mediating effects of the hippocampus and amygdala volumes were observed for either group. These results suggest that reduced ACC volume may represent part of the mechanism by which early life adversity results in poorer social cognitive function. Confirmation of the causal basis of this association would highlight the importance of resilience-building interventions to mitigate the detrimental effects of childhood trauma on brain structure and function.
Identifiants
pubmed: 33245126
pii: 6007452
doi: 10.1093/scan/nsaa160
pmc: PMC7759212
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1336-1350Informations de copyright
© The Author(s) 2020. Published by Oxford University Press.
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