A multi-scale cortical wiring space links cellular architecture and functional dynamics in the human brain.
Adult
Brain
/ anatomy & histology
Cerebral Cortex
/ anatomy & histology
Connectome
/ methods
Diffusion Magnetic Resonance Imaging
Drug Resistant Epilepsy
/ diagnostic imaging
Electrocorticography
Epilepsies, Partial
/ diagnostic imaging
Female
Functional Neuroimaging
Humans
Machine Learning
Male
Models, Anatomic
Models, Neurological
Nerve Net
/ anatomy & histology
Young Adult
Journal
PLoS biology
ISSN: 1545-7885
Titre abrégé: PLoS Biol
Pays: United States
ID NLM: 101183755
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
26
03
2020
accepted:
02
11
2020
revised:
10
12
2020
pubmed:
1
12
2020
medline:
5
1
2021
entrez:
30
11
2020
Statut:
epublish
Résumé
The vast net of fibres within and underneath the cortex is optimised to support the convergence of different levels of brain organisation. Here, we propose a novel coordinate system of the human cortex based on an advanced model of its connectivity. Our approach is inspired by seminal, but so far largely neglected models of cortico-cortical wiring established by postmortem anatomical studies and capitalises on cutting-edge in vivo neuroimaging and machine learning. The new model expands the currently prevailing diffusion magnetic resonance imaging (MRI) tractography approach by incorporation of additional features of cortical microstructure and cortico-cortical proximity. Studying several datasets and different parcellation schemes, we could show that our coordinate system robustly recapitulates established sensory-limbic and anterior-posterior dimensions of brain organisation. A series of validation experiments showed that the new wiring space reflects cortical microcircuit features (including pyramidal neuron depth and glial expression) and allowed for competitive simulations of functional connectivity and dynamics based on resting-state functional magnetic resonance imaging (rs-fMRI) and human intracranial electroencephalography (EEG) coherence. Our results advance our understanding of how cell-specific neurobiological gradients produce a hierarchical cortical wiring scheme that is concordant with increasing functional sophistication of human brain organisation. Our evaluations demonstrate the cortical wiring space bridges across scales of neural organisation and can be easily translated to single individuals.
Identifiants
pubmed: 33253185
doi: 10.1371/journal.pbio.3000979
pii: PBIOLOGY-D-20-00780
pmc: PMC7728398
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3000979Subventions
Organisme : CIHR
ID : FDN-154298
Pays : Canada
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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