Transcriptomic changes in pancreatic islets, adipose and liver after Roux-en-Y gastric bypass in a diet-induced obese rat model.
Adipose Tissue
/ metabolism
Animals
Diet, High-Fat
/ adverse effects
Disease Models, Animal
Gastric Bypass
Humans
Insulin Resistance
/ genetics
Islets of Langerhans
/ metabolism
Liver
/ metabolism
Male
Obesity
/ etiology
Obesity, Morbid
/ genetics
Rats
Rats, Sprague-Dawley
Transcriptome
/ genetics
Weight Loss
/ genetics
Gene expression
Inflammation
Metabolism
RNA sequencing
Rat model
Roux-en-Y gastric bypass
Journal
Peptides
ISSN: 1873-5169
Titre abrégé: Peptides
Pays: United States
ID NLM: 8008690
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
27
08
2020
revised:
28
10
2020
accepted:
21
11
2020
pubmed:
1
12
2020
medline:
15
12
2021
entrez:
30
11
2020
Statut:
ppublish
Résumé
Roux-en-Y gastric bypass (RYGB) is the most efficient intervention in morbid obesity and promotes metabolic improvements in several peripheral tissues. However, the underlying molecular mechanisms are still poorly understood. To further understand the effects of RYGB on peripheral tissues transcriptomes, we determined transcriptome signatures in pancreatic islets, adipose and liver tissue from diet-induced obese (DIO) rats model following RYGB. Whereas RYGB led to discrete gene expression changes in pancreatic islets, substantial transcriptome changes were observed in metabolic and immune signaling pathways in adipose tissue and the liver, indicating major gene adaptive responses in fat-storing tissues. Compared to RYGB DIO rats, peripheral tissue transcriptome signatures were markedly different in caloric restricted weight matching DIO rats, implying that caloric restriction paradigms do not reflect transcriptomic regulations of RYGB induced weight loss. The present gene expression study may serve as a basis for further investigations into molecular regulatory effects in peripheral tissues following RYGB-induced weight loss.
Identifiants
pubmed: 33253774
pii: S0196-9781(20)30216-3
doi: 10.1016/j.peptides.2020.170467
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
170467Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.