Niels Vrang

Affiliations

Gubra Aps, Hoersholm, Denmark.

Publications (34)

Validity of biopsy-based drug effects in a diet-induced obese mouse model of biopsy-confirmed NASH.

BMC gastroenterology

Avec: Maria Nicoline Baandrup Kristiansen , Sanne Skovgård Veidal , Christina Christoffersen , Michael Feigh , Niels Vrang , Jonathan David Roth , Mary Erickson , Luciano Adorini , Jacob Jelsing

Global transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss.

Scientific reports

Avec: Pernille Barkholt , Kristoffer T G Rigbolt , Mechthilde Falkenhahn , Thomas Hübschle , Uwe Schwahn , Maria Luisa Fernandez-Cachon , Thorsten Schmidt , Stefan Theis , Henrik H Hansen , Anders Hay-Schmidt , Philip J Pedersen , Niels Vrang , Jacob Jelsing

Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson's disease.

Disease models & mechanisms

Avec: Urmas Roostalu , Casper B G Salinas , Ditte D Thorbek , Jacob L Skytte , Katrine Fabricius , Pernille Barkholt , Linu M John , Vanessa Isabell Jurtz , Lotte Bjerre Knudsen , Jacob Jelsing , Niels Vrang , Henrik H Hansen , Jacob Hecksher-Sørensen

The dorsomedial hypothalamus and nucleus of the solitary tract as key regulators in a rat model of chronic obesity.

Brain research

Avec: Chen Zhang , Pernille Barkholt , Jens Christian Nielsen , Ditte Dencker Thorbek , Kristoffer Rigbolt , Niels Vrang , David Paul Drucker Woldbye , Jacob Jelsing

Identification and Metabolic Profiling of a Novel Human Gut-derived LEAP2 Fragment.

The Journal of clinical endocrinology and metabolism

Avec: Christoffer A Hagemann , Chen Zhang , Henrik H Hansen , Tina Jorsal , Kristoffer T G Rigbolt , Martin R Madsen , Natasha C Bergmann , Sebastian M N Heimbürger , Mechthilde Falkenhahn , Stefan Theis , Kristin Breitschopf , Stephanie Holm , Morten A Hedegaard , Mikkel B Christensen , Tina Vilsbøll , Birgitte Holst , Niels Vrang , Jacob Jelsing , Filip K Knop

Whole-brain activation signatures of weight-lowering drugs.

Molecular metabolism

Avec: Henrik H Hansen , Johanna Perens , Urmas Roostalu , Jacob Lercke Skytte , Casper Gravesen Salinas , Pernille Barkholt , Ditte Dencker Thorbek , Kristoffer T G Rigbolt , Niels Vrang , Jacob Jelsing , Jacob Hecksher-Sørensen

Automated Image Analyses of Glomerular Hypertrophy in a Mouse Model of Diabetic Nephropathy.

Kidney360

Avec: Mette V Østergaard , Frederikke E Sembach , Jacob L Skytte , Urmas Roostalu , Thomas Secher , Agnete Overgaard , Lisbeth N Fink , Niels Vrang , Jacob Jelsing , Jacob Hecksher-Sørensen

Identification of GDF15 peptide fragments inhibiting GFRAL receptor signaling.

Peptides

Avec: Flora Alexopoulou , Nina Buch-Månson , Søren Ljungberg Pedersen , Niels Vrang , Lisbeth Nielsen Fink , Kristian Strømgaard

Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH.

Scientific reports

Avec: Jonathan D Roth , Sanne S Veidal , Louise K D Fensholdt , Kristoffer T G Rigbolt , Romeo Papazyan , Jens Christian Nielsen , Michael Feigh , Niels Vrang , Mark Young , Jacob Jelsing , Luciano Adorini , Henrik H Hansen

Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source.

World journal of gastroenterology

Avec: Michelle L Boland , Denise Oró , Kirstine S Tølbøl , Sebastian T Thrane , Jens Christian Nielsen , Taylor S Cohen , David E Tabor , Fiona Fernandes , Andrey Tovchigrechko , Sanne S Veidal , Paul Warrener , Bret R Sellman , Jacob Jelsing , Michael Feigh , Niels Vrang , James L Trevaskis , Henrik H Hansen

Effect of captopril on post-infarction remodelling visualized by light sheet microscopy and echocardiography.

Scientific reports

Avec: Urmas Roostalu , Louise Thisted , Jacob Lercke Skytte , Casper Gravesen Salinas , Philip Juhl Pedersen , Jacob Hecksher-Sørensen , Bidda Rolin , Henrik H Hansen , James G MacKrell , Robert M Christie , Niels Vrang , Jacob Jelsing , Nora Elisabeth Zois

Characterization of combined linagliptin and Y2R agonist treatment in diet-induced obese mice.

Scientific reports

Avec: Henrik H Hansen , Rikke V Grønlund , Tamara Baader-Pagler , Peter Haebel , Harald Tammen , Leif Kongskov Larsen , Jacob Jelsing , Niels Vrang , Thomas Klein

Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH.

Clinical and translational science

Avec: Mathias B Møllerhøj , Sanne S Veidal , Kirstine Tølbøl Thrane , Denise Oró , Agnete Overgaard , Casper Gravesen Salinas , Martin Rønn Madsen , Larissa Pfisterer , Mogens Vyberg , Eric Simon , Andre Broermann , Niels Vrang , Jacob Jelsing , Michael Feigh , Henrik H Hansen

Impact of sex on diabetic nephropathy and the renal transcriptome in UNx db/db C57BLKS mice.

Physiological reports

Avec: Frederikke E Sembach , Lisbeth N Fink , Thea Johansen , Brandon B Boland , Thomas Secher , Sebastian T Thrane , Jens C Nielsen , Keld Fosgerau , Niels Vrang , Jacob Jelsing , Tanja X Pedersen , Mette V Østergaard

The preprohormone expression profile of enteroendocrine cells following Roux-en-Y gastric bypass in rats.

Peptides

Avec: Chen Zhang , Kristoffer Rigbolt , Søren Ljungberg Petersen , Lise Christine Biehl Rudkjær , Uwe Schwahn , Maria Luisa Fernandez-Cachon , Martin Bossart , Mechthilde Falkenhahn , Stefan Theis , Thomas Hübschle , Thorsten Schmidt , Philip Just Larsen , Niels Vrang , Jacob Jelsing

An Aldehyde Responsive, Cleavable Linker for Glucose Responsive Insulins.

Chemistry (Weinheim an der Bergstrasse, Germany)

Avec: Karin Mannerstedt , Narendra Kumar Mishra , Ebbe Engholm , Morten Lundh , Charlotte S Madsen , Philip J Pedersen , Priska Le-Huu , Søren L Pedersen , Nina Buch-Månson , Björn Borgström , Thomas Brimert , Lisbeth N Fink , Keld Fosgerau , Niels Vrang , Knud J Jensen

Transcriptomic changes in pancreatic islets, adipose and liver after Roux-en-Y gastric bypass in a diet-induced obese rat model.

Peptides

Avec: Chen Zhang , Lise Christine Biehl Rudkjær , Marisa Fernández Cachón , Mechthilde Falkenhahn , Stefan Theis , Thorsten Schmidt , Niels Vrang , Jacob Jelsing , Kristoffer Rigbolt

Gut Mucosal Gene Expression and Metabolic Changes After Roux-en-Y Gastric Bypass Surgery.

Obesity (Silver Spring, Md.)

Avec: Tina Jorsal , Marie M Christensen , Brynjulf Mortensen , Eva B Nygaard , Chen Zhang , Kristoffer Rigbolt , Erik Wandall , Ebbe Langholz , Steffen Friis , Dorte Worm , Andrea Floyd , Frederik Helgstrand , René K Støving , Alin R Aldries , Claus B Juhl , Torben Østergaard , Thomas Rydborg , Julie L Forman , Frederik Sørensen , Torsten Schmidt , Mechthilde Falkenhahn , Petra B Musholt , Stefan Theis , Philip J Larsen , Jens F Rehfeld , Niels Vrang , Jacob Jelsing , Tina Vilsbøll , Filip K Knop

3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II.

Disease models & mechanisms

Avec: Urmas Roostalu , Jacob Lercke Skytte , Casper Gravesen Salinas , Thomas Klein , Niels Vrang , Jacob Jelsing , Jacob Hecksher-Sørensen

An Optimized Mouse Brain Atlas for Automated Mapping and Quantification of Neuronal Activity Using iDISCO+ and Light Sheet Fluorescence Microscopy.

Neuroinformatics

Avec: Johanna Perens , Casper Gravesen Salinas , Jacob Lercke Skytte , Urmas Roostalu , Anders Bjorholm Dahl , Tim B Dyrby , Franziska Wichern , Pernille Barkholt , Niels Vrang , Jacob Jelsing , Jacob Hecksher-Sørensen

Whole-brain mapping of amylin-induced neuronal activity in receptor activity-modifying protein 1/3 knockout mice.

The European journal of neuroscience

Avec: Grethe Skovbjerg , Urmas Roostalu , Henrik H Hansen , Thomas A Lutz , Christelle Le Foll , Casper G Salinas , Jacob L Skytte , Jacob Jelsing , Niels Vrang , Jacob Hecksher-Sørensen

Integrative transcriptomic profiling of a mouse model of hypertension-accelerated diabetic kidney disease.

Disease models & mechanisms

Avec: Frederikke E Sembach , Helene M Ægidius , Lisbeth N Fink , Thomas Secher , Annemarie Aarup , Jacob Jelsing , Niels Vrang , Bo Feldt-Rasmussen , Kristoffer T G Rigbolt , Jens C Nielsen , Mette V Østergaard

Lipidated PrRP31 metabolites are long acting dual GPR10 and NPFF2 receptor agonists with potent body weight lowering effect.

Scientific reports

Avec: Flora Alexopoulou , Esben Matzen Bech , Søren Ljungberg Pedersen , Ditte Dencker Thorbek , Ulrike Leurs , Lise Christine Biehl Rudkjær , Keld Fosgerau , Henrik H Hansen , Niels Vrang , Jacob Jelsing , Lisbeth Elster

Hepatoprotective effects of the long-acting fibroblast growth factor 21 analog PF-05231023 in the GAN diet-induced obese and biopsy-confirmed mouse model of nonalcoholic steatohepatitis.

American journal of physiology. Gastrointestinal and liver physiology

Avec: Malte Hasle Nielsen , Matthew P Gillum , Niels Vrang , Jacob Jelsing , Henrik H Hansen , Michael Feigh , Denise Oró

Characterization of local gut microbiome and intestinal transcriptome responses to rosiglitazone treatment in diabetic db/db mice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Avec: Mette Simone Aae Madsen , Rikke Veggerby Grønlund , John Eid , Mikkel Christensen-Dalsgaard , Morten Sommer , Kristoffer Rigbolt , Martin Rønn Madsen , Jacob Jelsing , Niels Vrang , Henrik H Hansen , Martin Mikkelsen

Investigating Intestinal Glucagon After Roux-en-Y Gastric Bypass Surgery.

The Journal of clinical endocrinology and metabolism

Avec: Tina Jorsal , Nicolai J Wewer Albrechtsen , Marie M Christensen , Brynjulf Mortensen , Erik Wandall , Ebbe Langholz , Steffen Friis , Dorte Worm , Cathrine Ørskov , René K Støving , Alin Andries , Claus B Juhl , Frederik Sørensen , Julie L Forman , Mechthilde Falkenhahn , Petra B Musholt , Stefan Theis , Philip J Larsen , Jens J Holst , Niels Vrang , Jacob Jelsing , Tina Vilsbøll , Filip K Knop

Metabolic and gut microbiome changes following GLP-1 or dual GLP-1/GLP-2 receptor agonist treatment in diet-induced obese mice.

Scientific reports

Avec: Mette Simone Aae Madsen , Jacob Bak Holm , Albert Pallejà , Pernille Wismann , Katrine Fabricius , Kristoffer Rigbolt , Martin Mikkelsen , Morten Sommer , Jacob Jelsing , Henrik Bjørn Nielsen , Niels Vrang , Henrik H Hansen

Hepatic transcriptome signatures in patients with varying degrees of nonalcoholic fatty liver disease compared with healthy normal-weight individuals.

American journal of physiology. Gastrointestinal and liver physiology

Avec: Malte P Suppli , Kristoffer T G Rigbolt , Sanne S Veidal , Sara Heebøll , Peter Lykke Eriksen , Mia Demant , Jonatan I Bagger , Jens Christian Nielsen , Denise Oró , Sebastian W Thrane , Asger Lund , Charlotte Strandberg , Merete J Kønig , Tina Vilsbøll , Niels Vrang , Karen L Thomsen , Henning Grønbæk , Jacob Jelsing , Henrik H Hansen , Filip K Knop

Disease Progression and Pharmacological Intervention in a Nutrient-Deficient Rat Model of Nonalcoholic Steatohepatitis.

Digestive diseases and sciences

Avec: Kirstine S Tølbøl , Birgit Stierstorfer , Jörg F Rippmann , Sanne S Veidal , Kristoffer T G Rigbolt , Tanja Schönberger , Matthew P Gillum , Henrik H Hansen , Niels Vrang , Jacob Jelsing , Michael Feigh , Andre Broermann

Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis.

Scientific reports

Avec: Helene M Ægidius , Sanne S Veidal , Michael Feigh , Philip Hallenborg , Michele Puglia , Tune H Pers , Niels Vrang , Jacob Jelsing , Birgitte R Kornum , Blagoy Blagoev , Kristoffer T G Rigbolt

Rodent models of diabetic kidney disease: human translatability and preclinical validity.

Drug discovery today

Avec: Frederikke E Sembach , Mette V Østergaard , Niels Vrang , Bo Feldt-Rasmussen , Keld Fosgerau , Jacob Jelsing , Lisbeth N Fink

Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis.

BMC gastroenterology

Avec: Henrik H Hansen , Helene M Ægidius , Denise Oró , Simon S Evers , Sara Heebøll , Peter Lykke Eriksen , Karen Louise Thomsen , Anja Bengtsson , Sanne S Veidal , Michel Feigh , Malte P Suppli , Filip K Knop , Henning Grønbæk , Diego Miranda , James L Trevaskis , Niels Vrang , Jacob Jelsing , Kristoffer T G Rigbolt

Therapeutic effects of lisinopril and empagliflozin in a mouse model of hypertension-accelerated diabetic kidney disease.

American journal of physiology. Renal physiology

Avec: Mette V Østergaard , Thomas Secher , Michael Christensen , Casper Gravesen Salinas , Urmas Roostalu , Jacob Lercke Skytte , Ida Rune , Henrik H Hansen , Jacob Jelsing , Niels Vrang , Lisbeth N Fink

Machine-Learning-Guided Peptide Drug Discovery: Development of GLP-1 Receptor Agonists with Improved Drug Properties.

Journal of medicinal chemistry

Avec: Jens Christian Nielsen , Claudia Hjo Rringgaard , Mads Mo Rup Nygaard , Anita Wester , Lisbeth Elster , Trine Porsgaard , Randi Bonke Mikkelsen , Silas Rasmussen , Andreas Nygaard Madsen , Morten Schlein , Niels Vrang , Kristoffer Rigbolt , Louise S Dalbo Ge

Réseau de co-auteurs

Jacob Jelsing 31 collaborations

Henrik H Hansen 18 collaborations

Kristoffer T G Rigbolt 9 collaborations

Urmas Roostalu 8 collaborations

Michael Feigh 7 collaborations

Jacob Hecksher-Sørensen 7 collaborations

Kristoffer Rigbolt 7 collaborations

Sanne S Veidal 7 collaborations

Mechthilde Falkenhahn 6 collaborations

Stefan Theis 6 collaborations

Casper Gravesen Salinas 6 collaborations

Lisbeth N Fink 6 collaborations

Pernille Barkholt 5 collaborations

Chen Zhang 5 collaborations

Jens Christian Nielsen 5 collaborations

Filip K Knop 5 collaborations

Jacob Lercke Skytte 5 collaborations

Mette V Østergaard 5 collaborations

Denise Oró 5 collaborations

Tina Vilsbøll 4 collaborations

Frederikke E Sembach 4 collaborations

Thomas Secher 4 collaborations

Keld Fosgerau 4 collaborations

Thorsten Schmidt 3 collaborations

Jacob L Skytte 3 collaborations

Ditte Dencker Thorbek 3 collaborations

Tina Jorsal 3 collaborations

Lise Christine Biehl Rudkjær 3 collaborations

Helene M Ægidius 3 collaborations

Luciano Adorini 2 collaborations

Thomas Hübschle 2 collaborations

Uwe Schwahn 2 collaborations

Maria Luisa Fernandez-Cachon 2 collaborations

Philip J Pedersen 2 collaborations

Katrine Fabricius 2 collaborations

Johanna Perens 2 collaborations

Agnete Overgaard 2 collaborations

Flora Alexopoulou 2 collaborations

Nina Buch-Månson 2 collaborations

Søren Ljungberg Pedersen 2 collaborations

Kirstine S Tølbøl 2 collaborations

Sebastian T Thrane 2 collaborations

James L Trevaskis 2 collaborations

Thomas Klein 2 collaborations

Martin Rønn Madsen 2 collaborations

Andre Broermann 2 collaborations

Jens C Nielsen 2 collaborations

Marie M Christensen 2 collaborations

Brynjulf Mortensen 2 collaborations

Erik Wandall 2 collaborations

Ebbe Langholz 2 collaborations

Steffen Friis 2 collaborations

Dorte Worm 2 collaborations

René K Støving 2 collaborations

Claus B Juhl 2 collaborations

Julie L Forman 2 collaborations

Frederik Sørensen 2 collaborations

Petra B Musholt 2 collaborations

Philip J Larsen 2 collaborations

Bo Feldt-Rasmussen 2 collaborations

Lisbeth Elster 2 collaborations

Matthew P Gillum 2 collaborations

Mette Simone Aae Madsen 2 collaborations

Morten Sommer 2 collaborations

Martin Mikkelsen 2 collaborations

Malte P Suppli 2 collaborations

Sara Heebøll 2 collaborations

Peter Lykke Eriksen 2 collaborations

Henning Grønbæk 2 collaborations

Maria Nicoline Baandrup Kristiansen 1 collaboration

Sanne Skovgård Veidal 1 collaboration

Christina Christoffersen 1 collaboration

Jonathan David Roth 1 collaboration

Mary Erickson 1 collaboration

Anders Hay-Schmidt 1 collaboration

Casper B G Salinas 1 collaboration

Ditte D Thorbek 1 collaboration

Linu M John 1 collaboration

Vanessa Isabell Jurtz 1 collaboration

Lotte Bjerre Knudsen 1 collaboration

David Paul Drucker Woldbye 1 collaboration

Christoffer A Hagemann 1 collaboration

Martin R Madsen 1 collaboration

Natasha C Bergmann 1 collaboration

Sebastian M N Heimbürger 1 collaboration

Kristin Breitschopf 1 collaboration

Stephanie Holm 1 collaboration

Morten A Hedegaard 1 collaboration

Mikkel B Christensen 1 collaboration

Birgitte Holst 1 collaboration

Lisbeth Nielsen Fink 1 collaboration

Kristian Strømgaard 1 collaboration

Jonathan D Roth 1 collaboration

Louise K D Fensholdt 1 collaboration

Romeo Papazyan 1 collaboration

Mark Young 1 collaboration

Michelle L Boland 1 collaboration

Taylor S Cohen 1 collaboration

David E Tabor 1 collaboration

Fiona Fernandes 1 collaboration

Andrey Tovchigrechko 1 collaboration

Paul Warrener 1 collaboration

Bret R Sellman 1 collaboration

Louise Thisted 1 collaboration

Philip Juhl Pedersen 1 collaboration

Bidda Rolin 1 collaboration

James G MacKrell 1 collaboration

Robert M Christie 1 collaboration

Nora Elisabeth Zois 1 collaboration

Rikke V Grønlund 1 collaboration

Tamara Baader-Pagler 1 collaboration

Peter Haebel 1 collaboration

Harald Tammen 1 collaboration

Leif Kongskov Larsen 1 collaboration

Mathias B Møllerhøj 1 collaboration

Kirstine Tølbøl Thrane 1 collaboration

Larissa Pfisterer 1 collaboration

Mogens Vyberg 1 collaboration

Eric Simon 1 collaboration

Thea Johansen 1 collaboration

Brandon B Boland 1 collaboration

Tanja X Pedersen 1 collaboration

Søren Ljungberg Petersen 1 collaboration

Martin Bossart 1 collaboration

Philip Just Larsen 1 collaboration

Karin Mannerstedt 1 collaboration

Narendra Kumar Mishra 1 collaboration

Ebbe Engholm 1 collaboration

Morten Lundh 1 collaboration

Charlotte S Madsen 1 collaboration

Priska Le-Huu 1 collaboration

Søren L Pedersen 1 collaboration

Björn Borgström 1 collaboration

Thomas Brimert 1 collaboration

Knud J Jensen 1 collaboration

Marisa Fernández Cachón 1 collaboration

Eva B Nygaard 1 collaboration

Andrea Floyd 1 collaboration

Frederik Helgstrand 1 collaboration

Alin R Aldries 1 collaboration

Torben Østergaard 1 collaboration

Thomas Rydborg 1 collaboration

Torsten Schmidt 1 collaboration

Jens F Rehfeld 1 collaboration

Anders Bjorholm Dahl 1 collaboration

Tim B Dyrby 1 collaboration

Franziska Wichern 1 collaboration

Grethe Skovbjerg 1 collaboration

Thomas A Lutz 1 collaboration

Christelle Le Foll 1 collaboration

Casper G Salinas 1 collaboration

Annemarie Aarup 1 collaboration

Esben Matzen Bech 1 collaboration

Ulrike Leurs 1 collaboration

Malte Hasle Nielsen 1 collaboration

Rikke Veggerby Grønlund 1 collaboration

John Eid 1 collaboration

Mikkel Christensen-Dalsgaard 1 collaboration

Nicolai J Wewer Albrechtsen 1 collaboration

Cathrine Ørskov 1 collaboration

Alin Andries 1 collaboration

Jens J Holst 1 collaboration

Jacob Bak Holm 1 collaboration

Albert Pallejà 1 collaboration

Pernille Wismann 1 collaboration

Henrik Bjørn Nielsen 1 collaboration

Mia Demant 1 collaboration

Jonatan I Bagger 1 collaboration

Sebastian W Thrane 1 collaboration

Asger Lund 1 collaboration

Charlotte Strandberg 1 collaboration

Merete J Kønig 1 collaboration

Karen L Thomsen 1 collaboration

Birgit Stierstorfer 1 collaboration

Jörg F Rippmann 1 collaboration

Tanja Schönberger 1 collaboration

Philip Hallenborg 1 collaboration

Michele Puglia 1 collaboration

Tune H Pers 1 collaboration

Birgitte R Kornum 1 collaboration

Blagoy Blagoev 1 collaboration

Simon S Evers 1 collaboration

Karen Louise Thomsen 1 collaboration

Anja Bengtsson 1 collaboration

Michel Feigh 1 collaboration

Diego Miranda 1 collaboration

Michael Christensen 1 collaboration

Ida Rune 1 collaboration

Claudia Hjo Rringgaard 1 collaboration

Mads Mo Rup Nygaard 1 collaboration

Anita Wester 1 collaboration

Trine Porsgaard 1 collaboration

Randi Bonke Mikkelsen 1 collaboration

Silas Rasmussen 1 collaboration

Andreas Nygaard Madsen 1 collaboration

Morten Schlein 1 collaboration

Louise S Dalbo Ge 1 collaboration