Association of fatty acid ethyl esters in meconium with behavior during childhood.
Alcohol Drinking
Biomarkers
/ analysis
Child
Child Behavior
/ physiology
Child, Preschool
Cohort Studies
Esters
/ analysis
Ethanol
/ analysis
Female
Humans
Infant, Newborn
Linolenic Acids
Longitudinal Studies
Male
Meconium
/ chemistry
Oleic Acids
Pregnancy
Prenatal Exposure Delayed Effects
Prospective Studies
Biomarkers
CBCL
Child aggression
Delinquency
Fatty acid ethyl esters
Prenatal alcohol exposure
Journal
Drug and alcohol dependence
ISSN: 1879-0046
Titre abrégé: Drug Alcohol Depend
Pays: Ireland
ID NLM: 7513587
Informations de publication
Date de publication:
01 01 2021
01 01 2021
Historique:
received:
29
07
2020
revised:
27
10
2020
accepted:
12
11
2020
pubmed:
2
12
2020
medline:
12
5
2021
entrez:
1
12
2020
Statut:
ppublish
Résumé
To examine associations between amounts of fatty acid ethyl esters (FAEEs) in meconium and behavior in school aged children exposed to alcohol and drugs in utero. A secondary analysis of a prospective cohort of cocaine, polydrug exposed children, primarily African-American, low socioeconomic status, recruited at birth into a longitudinal study. FAEEs were quantified with gas chromatography via a flame ionization detector. Meconium was analyzed for FAEEs for 216 newborns of whom 194 were assessed with the Child Behavior Checklist (CBCL) at ages 4, 6, 9, 10, 11, and 12. Generalized estimating equation analyses were used to assess the relationship of quantity of FAEEs to outcomes, controlling for maternal psychological distress. Higher concentrations of FAEEs (ethyl myristate, ethyl palmitate, ethyl oleate, ethyl linoleate, and ethyl linolenate) were associated with caregiver reported aggressive and/or delinquent behavior at ages 10 and 12. After control for caregiver psychological distress, and age, significant (p < 0.05) FAEE by age interactions were found for ethyl myristate for aggression and for ethyl oleate, ethyl linoleate and ethyl linolenate for delinquency. Thus, higher concentrations of FAEE were related to more caregiver reported aggressive and delinquent behaviors of clinical significance at ages 10 and 12. Higher concentrations of FAEEs in meconium are potential markers for children at risk for aggressive and delinquent behaviors related to the effects of prenatal alcohol exposure.
Identifiants
pubmed: 33257196
pii: S0376-8716(20)30602-5
doi: 10.1016/j.drugalcdep.2020.108437
pmc: PMC10189738
mid: NIHMS1650119
pii:
doi:
Substances chimiques
Biomarkers
0
Esters
0
Linolenic Acids
0
Oleic Acids
0
Ethanol
3K9958V90M
ethyl linolenate
T54Y8H042V
ethyl oleate
Z2Z439864Y
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108437Subventions
Organisme : NCRR NIH HHS
ID : M01 RR000080
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA007957
Pays : United States
Organisme : NIDA NIH HHS
ID : R34 DA050342
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
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