TIN2
cancer biology
cancer predisposition
human
telomere length
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
01 12 2020
01 12 2020
Historique:
received:
20
07
2020
accepted:
11
11
2020
entrez:
1
12
2020
pubmed:
2
12
2020
medline:
9
3
2021
Statut:
epublish
Résumé
Telomere shortening is a presumed tumor suppressor pathway that imposes a proliferative barrier (the Hayflick limit) during tumorigenesis. This model predicts that excessively long somatic telomeres predispose to cancer. Here, we describe cancer-prone families with two unique
Identifiants
pubmed: 33258446
doi: 10.7554/eLife.61235
pii: 61235
pmc: PMC7707837
doi:
pii:
Substances chimiques
TINF2 protein, human
0
Telomere-Binding Proteins
0
Telomeric Repeat Binding Protein 1
0
Tumor Suppressor Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : U.S. Department of Defense
ID : W81XWH-19-1-0586
Pays : International
Organisme : NCI NIH HHS
ID : R35 CA210036
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA196884
Pays : United States
Organisme : Melanoma Research Alliance
ID : 577521
Pays : United States
Organisme : American Cancer Society
ID : 133396-RSG-19-029-01-DMC
Pays : International
Informations de copyright
© 2020, Schmutz et al.
Déclaration de conflit d'intérêts
IS, AM, KT, MH, LS, Rd, SC, FL, Ev, DH, MJ No competing interests declared, Td Member of the SAB of Calico Life Sciences LLC
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