Zinc Binds to RRM2 Peptide of TDP-43.
QM/MM
TDP-43
zinc
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Nov 2020
29 Nov 2020
Historique:
received:
29
10
2020
revised:
24
11
2020
accepted:
25
11
2020
entrez:
2
12
2020
pubmed:
3
12
2020
medline:
6
3
2021
Statut:
epublish
Résumé
Transactive response DNA and RNA binding protein 43 kDa (TDP-43) is a highly conserved heterogeneous nuclear ribonucleoprotein (hnRNP), which is involved in several steps of protein production including transcription and splicing. Its aggregates are frequently observed in motor neurons from amyotrophic lateral sclerosis patients and in the most common variant of frontotemporal lobar degeneration. Recently it was shown that TDP-43 is able to bind Zn
Identifiants
pubmed: 33260324
pii: ijms21239080
doi: 10.3390/ijms21239080
pmc: PMC7730363
pii:
doi:
Substances chimiques
DNA-Binding Proteins
0
Peptides
0
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Russian Foundation for Basic Research
ID : 19-34-51043
Organisme : Russian Science Foundation
ID : 18-15-00357
Organisme : Ambassade de France à Moscou
ID : Metchnikov program
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