Understanding the Heterogeneity of Obesity and the Relationship to the Brain-Gut Axis.
Adolescent
Adult
Amino Acids
/ analysis
Body Mass Index
Brain
/ metabolism
Cross-Sectional Studies
Diet
Feces
/ chemistry
Female
Gastrointestinal Microbiome
Gastrointestinal Tract
/ metabolism
Hispanic or Latino
Humans
Male
Metabolic Diseases
/ complications
Middle Aged
Obesity
/ complications
Overweight
/ complications
RNA, Ribosomal, 16S
/ genetics
Sequence Analysis, RNA
Socioeconomic Factors
Young Adult
Hispanic
amino acids
brain-gut axis
diet
health disparity
heterogeneity
metabolites
microbiome
obesity
precision medicine
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
30 Nov 2020
30 Nov 2020
Historique:
received:
29
09
2020
revised:
16
11
2020
accepted:
20
11
2020
entrez:
3
12
2020
pubmed:
4
12
2020
medline:
4
5
2021
Statut:
epublish
Résumé
Obesity is best understood as a multifactorial metabolic imbalances disorder. In a cross-sectional study, we aimed to explore sociodemographic and dietary determinants of obesity in relation to brain-gut homeostasis among overweight and obese individuals. Multivariate logistic regression models were used to examine obesity and its association with sociodemographic and dietary factors. Biological variables examined included the gut microbiome, fecal amino acid metabolites and brain structural volumes. Among 130 participants, there were higher odds of obesity if individuals were Hispanic (adjusted odds ratio (aOR) 1.56,
Identifiants
pubmed: 33266058
pii: nu12123701
doi: 10.3390/nu12123701
pmc: PMC7761087
pii:
doi:
Substances chimiques
Amino Acids
0
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : VA
ID : IK2CX001717
Pays : United States
Organisme : NIH HHS
ID : K23 105628
Pays : United States
Organisme : UCLA CURE/CTSI Pilot and Feasibility Study
ID : ULTR001881/DK041301
Organisme : NIH HHS
ID : R01 DK048351
Pays : United States
Organisme : CSRD VA
ID : IK2 CX001717
Pays : United States
Organisme : Ahmanson-Lovelace Brain Mapping Center
ID : Pilot funds provided for brain scanning
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