ALDH4A1 is an atherosclerosis auto-antigen targeted by protective antibodies.
1-Pyrroline-5-Carboxylate Dehydrogenase
/ blood
Animals
Atherosclerosis
/ blood
Autoantibodies
/ blood
Autoantigens
/ blood
Autoimmunity
B-Lymphocytes
/ immunology
Biomarkers
/ blood
Cholesterol
/ blood
Diet, High-Fat
Disease Models, Animal
Disease Progression
Humans
Lipoproteins, LDL
/ blood
Male
Mice
Mice, Inbred C57BL
Plaque, Atherosclerotic
/ immunology
Proteomics
Receptors, LDL
/ deficiency
Single-Cell Analysis
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
03
12
2019
accepted:
05
10
2020
pubmed:
4
12
2020
medline:
26
2
2021
entrez:
3
12
2020
Statut:
ppublish
Résumé
Cardiovascular disease (CVD) is the leading cause of mortality in the world, with most CVD-related deaths resulting from myocardial infarction or stroke. The main underlying cause of thrombosis and cardiovascular events is atherosclerosis, an inflammatory disease that can remain asymptomatic for long periods. There is an urgent need for therapeutic and diagnostic options in this area. Atherosclerotic plaques contain autoantibodies
Identifiants
pubmed: 33268892
doi: 10.1038/s41586-020-2993-2
pii: 10.1038/s41586-020-2993-2
doi:
Substances chimiques
Autoantibodies
0
Autoantigens
0
Biomarkers
0
Lipoproteins, LDL
0
Receptors, LDL
0
Cholesterol
97C5T2UQ7J
1-Pyrroline-5-Carboxylate Dehydrogenase
EC 1.2.1.88
ALDH4A1 protein, human
EC 1.2.1.88
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
287-292Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
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