Quantitative assessment of the interactions between the organogermanium compound and saccharides using an NMR reporter molecule.
Cis-diol
Complex formation
Ge-132
Organogermanium
Saccharide
Sugar isomer
Journal
Carbohydrate research
ISSN: 1873-426X
Titre abrégé: Carbohydr Res
Pays: Netherlands
ID NLM: 0043535
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
07
09
2020
revised:
16
10
2020
accepted:
10
11
2020
pubmed:
5
12
2020
medline:
2
10
2021
entrez:
4
12
2020
Statut:
ppublish
Résumé
Poly-trans-[(2-carboxyethyl)germasesquioxane], Ge-132, is a water-soluble organogermanium compound reported to have physiological effects such as immunostimulatory and antiviral effects. The hydrolysate of Ge-132, 3-(trihydroxygermyl)propanoic acid (THGP), can interact with diols; therefore, it likely can interact with diol-containing sugars in sugar chains, glycoproteins, and glycolipids, which have important physiological functions. In this study, we quantitatively assessed the ability of THGP to interact with saccharides using nuclear magnetic resonance (NMR) spectroscopy and THGP derivatives. THGP was complexed by binding its trihydroxy group with saccharides in aqueous solutions via the cis-diol group rather than the trans-diol group. The spectra of THGP and monosaccharides indicated that THGP has a higher affinity for ketose than aldose. Moreover, the complexation ability between THGP and saccharides was influenced by the number of cis-diol groups on the saccharide structure. Thus, interactions of THGP with important biological sugars might be involved in the physiological functions of Ge-132.
Identifiants
pubmed: 33272559
pii: S0008-6215(20)30570-X
doi: 10.1016/j.carres.2020.108199
pii:
doi:
Substances chimiques
Monosaccharides
0
Organometallic Compounds
0
Germanium
00072J7XWS
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
108199Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.