Immunoglobulin T genes in Actinopterygii.
Holostei
IgT
Neopterygii
Journal
Fish & shellfish immunology
ISSN: 1095-9947
Titre abrégé: Fish Shellfish Immunol
Pays: England
ID NLM: 9505220
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
01
09
2020
revised:
21
11
2020
accepted:
24
11
2020
pubmed:
7
12
2020
medline:
18
5
2021
entrez:
6
12
2020
Statut:
ppublish
Résumé
In teleost fishes, there are three immunoglobulin isotypes named immunoglobulin M (IgM), D (IgD), and T (IgT). IgT was the last to be described in teleost fishes, and it is specific to them. From recent fish genomes, we identified and studied the immunoglobulin heavy chain genes in Actinopterygii. For this analysis, a custom bioinformatics and machine learning pipeline, we call CHfinder, was developed that identifies the exons coding for the CH domains of fish immunoglobulins. Some IgT in teleost and holostean fish found from this systematic study have not been previously described. Phylogenetic analysis of the deduced amino acid sequences of the IgT CH1 exons reveals they are similar to the CH1 of IgM. This analysis also shows that the other three domains (CH2, CH3, and CH4) were not the result of recent IgM duplication processes in Actinopterygii, demonstrating that it is an immunoglobulin of earlier origin. The bioinformatics program, CHfinder, is publicly available at https://github.com/compimmuno/CHfinder.
Identifiants
pubmed: 33279606
pii: S1050-4648(20)30737-3
doi: 10.1016/j.fsi.2020.11.027
pii:
doi:
Substances chimiques
Fish Proteins
0
Immunoglobulins
0
immunoglobulin T, teleost
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
86-93Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.